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Special Issue "Female Reproduction: The Link between Basic Ovarian Events and the Microenvironment of the Oocyte"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Prof. Dr. Eva Nagyova
E-Mail Website
Guest Editor
Institute of Animal Physiology and Genetics, Czech Academy of Sciences, 27721 Libechov, Czech Republic
Interests: oocyte; ovarian; Female Reproduction

Special Issue Information

Dear Colleagues,

Female fertility potential is based on the development of ovarian follicles, and ovarian pathologies constitute one of the main causes of infertility. The revelation of new targets involved in ovarian pathophysiology represents a significant scientific challenge. The fertilization of the mammalian oocyte requires tight interactions between the oocyte-cumulus extracellular matrix and spermatozoa. The expression of several essential components of the extracellular matrix has been confirmed in the mammalian ovarian follicles, and the impaired expression of their genes led to serious cumulus defects resulting in mice infertility. There is still an incomplete understanding of the specific changes that occur in the follicles leading to the modification of oocytes’ capacity to develop to the blastocyst stage. The elucidation of novel/unexplored signalling pathways that function as central regulators of cellular protein synthesis and metabolism in the oocyte microenvironment are of great interest.

Research focused on determining the follicular microenvironment produced by ovarian cells and its molecular characterisation could lead to the understanding of several fertility problems.

This Special Issue welcomes original research and review papers that aim to provide up-to-date reports on the link between basic ovarian events and the microenvironment of the oocyte.

Prof. Dr. Eva Nagyova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • female fertility
  • oocyte
  • ovarian pathologies
  • follicular microenvironment

Published Papers

This special issue is now open for submission.
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