Dear Colleagues,

Recently, a number of novel therapeutic agents have been developed for the treatment of advanced prostate cancer, including second-generation androgen-deprivation therapy, radionuclide therapy, PARP inhibitors, stereotactic body radiotherapy, and more recently, immunotherapy. While these treatments lead to improvements in overall survival, they have limited curative efficacy. Progress in characterizing the molecular landscape of metastatic prostate cancer has allowed important insights into mechanisms of therapeutic resistance against, and tumor progression towards lethal disease. For instance, lineage plasticity and neuroendocrine dedifferentiation have emerged as important mechanisms of resistance to androgen-deprivation therapy in prostate cancer. There is a critical need to understand the underpinnings of acquired resistance and develop rationalized therapeutic approaches for the treatment of prostate cancer.

This Special Issue of the International Journal of Molecular Sciences welcomes both original research articles and review papers addressing the molecular mechanisms involved in therapeutic resistance, lineage plasticity, and phenotypic reprogramming, leading to prostate cancer recurrence and, ultimately, lethal disease. We are particularly interested in manuscripts addressing molecular markers of treatment failure in prostate cancer patients, new molecular tools to overcome therapeutic resistance, and the development of novel therapeutics efficiently targeting metastatic tumors in pre-clinical models.

Prof. Dr. Natasha Kyprianou
Dr. Fabrice Lucien-Matteoni
Guest Editors

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• Prostate cancer
• Therapeutic resistance
• Lineage plasticity
• Neuroendocrine phenotype
• Androgen receptor
• Phenotypic reprogramming
• Novel targets
• Epigenetics
• Molecular signatures