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Special Issue "Second Messenger Analogs as Biochemical Tools and Prospective Drugs"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editor

Prof. Dr. Erik Maronde
E-Mail Website
Guest Editor
Dr. Senckenbergische Anatomie II, Faculty of Medicine, Goethe University, Frankfurt, Germany
Interests: cellular signal transduction; interaction of cellular signaling pathways; cellular pharmacology; chronobiology; clock genes

Special Issue Information

Dear Colleagues,

Nucleotides and inositol phosphates are examples of second messengers involved in cellular events, and some analogs of this type are promising enough to be tested as drugs. Other analogs have become standard tools for the investigation of biochemical and physiological signal transduction pathways, like the Rp-diastereomers of adenosine and guanosine 3`,5`-cyclic monophosphorothioate, as competitive inhibitors of cAMP- and cGMP-dependent protein kinases. Next generation analogs exhibit a higher membrane permeability, increased resistance against degradation, and improved target specificity, or are caged or photoactivatable for fast and/or targeted cellular imaging. Novel specific nucleotide analogs activating or inhibiting cyclic nucleotide-dependent ion channels, EPAC/GEF proteins, and bacterial target molecules have been developed, opening new avenues for basic and applied research. This Special Issue will highlight recent developments in second messenger analog research, as well as comment and elaborate on seminal findings in the field in the form of technical or review papers.

Prof. Dr. Erik Maronde
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • second messenger analogs
  • cAMP/cGMP
  • calcium
  • cAMP/cGMP-dependent protein kinase agonists
  • cAMP/cGMP-dependent protein kinase antagonists
  • caged second messenger analogs
  • nucleotide signalling

Published Papers

This special issue is now open for submission.
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