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Special Issue "Neural Signaling, Neuromodulation and Plasticity"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editor

Prof. Dr. Metin Akay
E-Mail Website
Guest Editor
University of Houston, Houston, United States
Interests: neural engineering; technologies for brain; neural rehabilitation; point-of-care diagnostics; healthcare innovations and entrepreneurship

Special Issue Information

Dear Colleagues,

Neurons are capable of sensing and responding to changes in their microenvironments via several receptors and channels. These highly diverse receptors and channels represent the dynamics of neuronal development and plasticity, which involve multiple highly complex, interactive, and dynamic signaling pathways.

To further understand the underlying complex molecular and cellular mechanisms behind neural signaling pathways and plasticity, in this Special Issue we aim to focus on:

1) The computational modeling of neural signaling and pathways;

2) Spatial synaptic modeling;

3) The interaction between spatial and temporal mapping and synaptic plasticity;

4) The influence of individual signaling pathways on the regulation of neural stem cells.

Prof. Dr. Metin Akay
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neural development
  • gene regularity pathways
  • neural plasticity
  • neural cell signaling
  • modelling
  • neuromodulation

Published Papers (1 paper)

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Research

Open AccessCommunication
Astrocyte Ca2+ Waves and Subsequent Non-Synchronized Ca2+ Oscillations Coincide with Arteriole Diameter Changes in Response to Spreading Depolarization
Int. J. Mol. Sci. 2021, 22(7), 3442; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22073442 - 26 Mar 2021
Viewed by 382
Abstract
Spreading depolarization (SD) is a wave of mass depolarization that causes profound perfusion changes in acute cerebrovascular diseases. Although the astrocyte response is secondary to the neuronal depolarization with SD, it remains to be explored how glial activity is altered after the passage [...] Read more.
Spreading depolarization (SD) is a wave of mass depolarization that causes profound perfusion changes in acute cerebrovascular diseases. Although the astrocyte response is secondary to the neuronal depolarization with SD, it remains to be explored how glial activity is altered after the passage of SD. Here, we describe post-SD high frequency astrocyte Ca2+ oscillations in the mouse somatosensory cortex. The intracellular Ca2+ changes of SR101 labeled astrocytes and the SD-related arteriole diameter variations were simultaneously visualized by multiphoton microscopy in anesthetized mice. Post-SD astrocyte Ca2+ oscillations were identified as Ca2+ events non-synchronized among astrocytes in the field of view. Ca2+ oscillations occurred minutes after the Ca2+ wave of SD. Furthermore, fewer astrocytes were involved in Ca2+ oscillations at a given time, compared to Ca2+ waves, engaging all astrocytes in the field of view simultaneously. Finally, our data confirm that astrocyte Ca2+ waves coincide with arteriolar constriction, while post-SD Ca2+ oscillations occur with the peak of the SD-related vasodilation. This is the first in vivo study to present the post-SD astrocyte Ca2+ oscillations. Our results provide novel insight into the spatio-temporal correlation between glial reactivity and cerebral arteriole diameter changes behind the SD wavefront. Full article
(This article belongs to the Special Issue Neural Signaling, Neuromodulation and Plasticity)
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