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Special Issue "Molecular Mechanisms of Sjögren's Syndrome 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Dr. Biji Theyilamannil Kurien
E-Mail Website
Guest Editor
Department of Veterans Affairs, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Interests: systemic lupus erythematosus; sjögren’s syndrome; prolidase deficiency; free radical biology; experimental urolithiasis; curcumin and other curcuminoids; dietary supplements; microgravity
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Special Issue Information

Dear Colleagues,

Sjögren’s syndrome (SS), a systemic autoimmune rheumatic disorder, is characterized by the B-cell infiltration of exocrine glands and the production of autoantibodies to self-antigens, such as Ro60 (SS-A), La (SS-B) and muscarinic 3 receptors. The most common symptoms of SS are dry eyes (keratoconjunctivitis sicca), dry mouth (xerostomia), and extreme tiredness. Additional symptoms include dryness of skin, nose, throat, vagina; arthralgias and myalgias, peripheral neuropathies, pulmonary, thyroid and renal disorders; and lymphoma. Increased tissue, serum cytokines and tissue fibrosis are also seen in SS subjects. Females account for 90% of all SS cases. Two age peaks have been identified for primary SS, the first after menarche (twenties to thirties), and the second following menopause (mid-fifties). SS can occur alone (primary SS) or along with another autoimmune disease (secondary SS), like systemic lupus erythematosus, rheumatoid arthritis, autoimmune hypothyroidism and systemic sclerosis. The molecular mechanisms mediating pathological dysfunction in SS remain to be elucidated, despite extensive studies investigating the underlying cause of Sjögren’s syndrome. There is no cure for Sjögren's syndrome currently, and treatment is mainly palliative.

In this Special Issue of IJMS, we are looking for articles that can pave the way to better understanding the molecular mechanisms mediating the pathological conditions of Sjögren’s syndrome. This would include articles that provide insights into molecular aspects of the initiation and progression of disease by glandular vascular endothelial cells, environmental triggers, free radical mediated oxidative damage, cytokine activation of lymphocytes, glandular lymphocyte and dendritic cell homing, the structure and function of autoantigens and autoantibody induction, germinal center-like structure formation, and the apoptosis of glandular cells. We also welcome review papers in these areas, as well as articles describing novel therapeutic targets and treatment options, new diagnostic tools, and biomarkers.

Dr. Biji Theyilamannil Kurien
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • autoimmunity
  • Sjögren’s syndrome
  • autoantibodies
  • salivary gland
  • lacrimal gland
  • dry eyes/mouth

Published Papers

This special issue is now open for submission.
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