Special Issue "Molecular Mechanisms of Sjögren's Syndrome 2.0"
Deadline for manuscript submissions: 31 October 2021.
Interests: systemic lupus erythematosus; sjögren’s syndrome; prolidase deficiency; free radical biology; experimental urolithiasis; curcumin and other curcuminoids; dietary supplements; microgravity
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Sjögren’s syndrome (SS), a systemic autoimmune rheumatic disorder, is characterized by the B-cell infiltration of exocrine glands and the production of autoantibodies to self-antigens, such as Ro60 (SS-A), La (SS-B) and muscarinic 3 receptors. The most common symptoms of SS are dry eyes (keratoconjunctivitis sicca), dry mouth (xerostomia), and extreme tiredness. Additional symptoms include dryness of skin, nose, throat, vagina; arthralgias and myalgias, peripheral neuropathies, pulmonary, thyroid and renal disorders; and lymphoma. Increased tissue, serum cytokines and tissue fibrosis are also seen in SS subjects. Females account for 90% of all SS cases. Two age peaks have been identified for primary SS, the first after menarche (twenties to thirties), and the second following menopause (mid-fifties). SS can occur alone (primary SS) or along with another autoimmune disease (secondary SS), like systemic lupus erythematosus, rheumatoid arthritis, autoimmune hypothyroidism and systemic sclerosis. The molecular mechanisms mediating pathological dysfunction in SS remain to be elucidated, despite extensive studies investigating the underlying cause of Sjögren’s syndrome. There is no cure for Sjögren's syndrome currently, and treatment is mainly palliative.
In this Special Issue of IJMS, we are looking for articles that can pave the way to better understanding the molecular mechanisms mediating the pathological conditions of Sjögren’s syndrome. This would include articles that provide insights into molecular aspects of the initiation and progression of disease by glandular vascular endothelial cells, environmental triggers, free radical mediated oxidative damage, cytokine activation of lymphocytes, glandular lymphocyte and dendritic cell homing, the structure and function of autoantigens and autoantibody induction, germinal center-like structure formation, and the apoptosis of glandular cells. We also welcome review papers in these areas, as well as articles describing novel therapeutic targets and treatment options, new diagnostic tools, and biomarkers.
Dr. Biji Theyilamannil Kurien
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- Sjögren’s syndrome
- salivary gland
- lacrimal gland
- dry eyes/mouth