Special Issue "Barrier Function of Skin and Oral Mucosa"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 May 2021).
Interests: skin; epidermis; stratum corneum; barrier function; lipids; ceramides
Special Issues, Collections and Topics in MDPI journals
Skin and oral mucosa have superficial permeability barriers that protect underlying viable tissue. Due to their physical properties, these barriers limit penetration of harmful substances.
In skin, stratum corneum (SC) is produced. SC cells are flat and are bounded by a cornified envelope (CE) consisting of polymerized proteins. The outer surface of the CE is coated by a monolayer of ω-hydroxyceramides (CLE). Between the CLEs of adjacent cell layers is a mixture of ceramides, cholesterol and fatty acids. The CLE and the intercellular lipids form multilamellar structures that determine the permeability of the skin.
In oral mucosa, the gingiva and hard palate produce SC. These regions do not have CLE, and intercellular lipid levels are lower. Buccal regions and the underside of the tongue are nonkeratinized. These regions do not produce SC. There is some evidence that lipid structures within the intercellular spaces may provide the barrier.
The purpose of this Special Issue is to present the current perspectives on the barrier function of skin and oral mucosa. Original research articles and reviews are welcome.
Prof. Dr. Philip Wertz
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- barrier function
- corneocyte lipid envelope
- fatty acids
- hexagonal packing
- long periodicity phase
- orthorombic packing
- short periodicity phase
- stratum corneum
- buccal absorption
- cubic phase
- electron microscopy
- lamellar phase
- permeability enhancement