Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.8
5.6
Journals
IJMS
Special Issues
Skin Cancer: From Pathophysiology to Novel Therapy
ijms-logo
Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Skin Cancer: From Pathophysiology to Novel Therapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (15 September 2023) | Viewed by 6190

Special Issue Editors

Dr. Carmen Cantisani

E-Mail Website
Guest Editor
Azienda Policlinico Umberto I, 00100 Rome, Italy
Interests: early diagnosis; actinic keratosis; daylight phodynamic therapy; methylaminolevulinate, videodermoscopy, confocal microscopy, optical coherence tomorography
Special Issues, Collections and Topics in MDPI journals
Dr. Giulio Tosti

E-Mail Website
Guest Editor
Istituto Europeo di Oncologia, 20141 Milan, Italy
Interests: vitamin D; melanoma; cancer; breslow; prognosis; single-nucleotide polymorphisms; gender; sex; risk factors; prognostic factors; predictive factors; meta-analysis; systematic review; precision medicine

Special Issue Information

Dear Colleagues,

Skin cancer is one of the most dreadful cancers that tends to gradually spread over other body parts. It is generally classified into two major categories: melanoma and nonmelanoma skin cancer. And melanoma is the most dangerous, and the incidence of it has been steadily growing. An in-depth study of the molecular pathology and physiology of skin cancer can lead to a better understanding of the underlying mechanisms of the neoplastic process and translate into possible benefits for treating the disease.

The purpose of this special issue is to provide research and reviews to gain insight into the molecular characterization and pathophysiology and non invasive diagnostic imaging of skin cancer, analyze the molecular mechanisms involved in tumorigenesis, and propose novel therapies. I cordially invite authors to submit original research and review articles to this Special Issue.

Dr. Carmen Cantisani
Dr. Giulio Tosti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

15 pages, 1691 KiB  
Article
Fraxetin Interacts Additively with Cisplatin and Mitoxantrone, Antagonistically with Docetaxel in Various Human Melanoma Cell Lines—An Isobolographic Analysis
by Paula Wróblewska-Łuczka, Aneta Grabarska, Agnieszka Góralczyk, Paweł Marzęda and Jarogniew J. Łuszczki
Int. J. Mol. Sci. 2023, 24(1), 212; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms24010212 - 22 Dec 2022
Cited by 4 | Viewed by 1167
Abstract
Malignant melanoma is a skin cancer characterized by rapid development, poor prognosis and high mortality. Due to the frequent drug resistance and/or early metastases in melanoma, new therapeutic methods are urgently needed. The study aimed at assessing the cytotoxic and antiproliferative effects of [...] Read more.
Malignant melanoma is a skin cancer characterized by rapid development, poor prognosis and high mortality. Due to the frequent drug resistance and/or early metastases in melanoma, new therapeutic methods are urgently needed. The study aimed at assessing the cytotoxic and antiproliferative effects of scoparone and fraxetin in vitro, when used alone and in combination with three cytostatics: cisplatin, mitoxantrone, and docetaxel in four human melanoma cell lines. Our experiments showed that scoparone in the concentration range tested up to 200 µM had no significant effect on the viability of human malignant melanoma (therefore, it was not possible to evaluate it in combination with other cytostatics), while fraxetin inhibited cell proliferation with IC50 doses in the range of 32.42–73.16 µM, depending on the cell line. Isobolographic analysis allowed for the assessment of the interactions between the studied compounds. Importantly, fraxetin was not cytotoxic to normal keratinocytes (HaCaT) and melanocytes (HEMa-LP), although it slightly inhibited their viability at high concentrations. The combination of fraxetin with cisplatin and mitoxantrone showed the additive interaction, which seems to be a promising direction in melanoma therapy. Unfortunately, the combination of fraxetin with docetaxel may not be beneficial due to the antagonistic antiproliferative effect of both drugs used in the mixture. Full article
(This article belongs to the Special Issue Skin Cancer: From Pathophysiology to Novel Therapy)
►▼ Show Figures

Figure 1

Review

Jump to: Research

12 pages, 566 KiB  
Review
The Complex Interplay between Nevi and Melanoma: Risk Factors and Precursors
by Rony Shreberk-Hassidim, Stephen M. Ostrowski and David E. Fisher
Int. J. Mol. Sci. 2023, 24(4), 3541; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms24043541 - 10 Feb 2023
Cited by 7 | Viewed by 4480
Abstract
One effort to combat the rising incidence of malignant melanoma is focused on early detection by the clinical and dermoscopic screening of melanocytic nevi. However, the interaction between nevi, which are congenital or acquired benign melanocytic proliferations, and melanoma is still enigmatic. On [...] Read more.
One effort to combat the rising incidence of malignant melanoma is focused on early detection by the clinical and dermoscopic screening of melanocytic nevi. However, the interaction between nevi, which are congenital or acquired benign melanocytic proliferations, and melanoma is still enigmatic. On the one hand, the majority of melanomas are thought to form de novo, as only a third of primary melanomas are associated with a histologically identifiable nevus precursor. On the other hand, an increased number of melanocytic nevi is a strong risk factor for developing melanoma, including melanomas that do not derive from nevi. The formation of nevi is modulated by diverse factors, including pigmentation, genetic risk factors, and environmental sun exposure. While the molecular alterations that occur during the progression of a nevus to melanoma have been well characterized, many unanswered questions remain surrounding the process of nevus to melanoma evolution. In this review, we discuss clinical, histological, molecular, and genetic factors that influence nevus formation and progression to melanoma. Full article
(This article belongs to the Special Issue Skin Cancer: From Pathophysiology to Novel Therapy)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop