Special Issue "Structure and Function of Small Heat Shock Proteins"
Deadline for manuscript submissions: 31 March 2021.
Interests: small heat shock proteins; postranslational modifications; protein-protein interactions; heterooligomeric complexes; congenital diseases
Small heat shock proteins form a very large and diverse family of proteins ubiquitously expressed in viruses, archaea, bacteria, plants and animals. Together with other chaperones small heat shock proteins control proper protein folding and prevent accumulation of denatured proteins in the cells. As a rule several isoforms of small heat shock proteins are simultaneously expressed in the cell and these isoforms can form both homo- and heterooligomeric complexes and can interact with other chaperones providing effective protein quality control. Small heat shock proteins undergo different posttranslational modifications that affect their structure, function and interaction with partner proteins. Small heat shock proteins are involved in many intra- and extracellular processes including control of redox state, proteasomal and autosomal protein degradation, apoptosis, regulation of cytoskeleton and muscle contraction, immunological response and many others. Mutations of small heat shock proteins correlate with many congenital disorders including cataract, different neurodegenerative diseases, cardiomyopathies and myopathies. Moreover, small heat shock proteins can be used as markers of different human diseases including cancer.
The goal of this special issue is to present the current knowledge on the structure and function of small heat shock proteins and their probable involvement in different cellular processes and human diseases.
We look forward to your contributions.
Prof. Dr. Nikolai B. Gusev
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- small heat shock proteins
- posttranslational modifications
- monomeric and oligomeric structure
- chaperone-like activity
- redox state regulation
- congenital diseases
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Alpha-crystallin: Is it possible to obtain a 3D reconstructed model of heterogeneous oligomer complexes?
Author: Oxana V. Galzitskaya
Title: Modulation of cortical actin dynamics during mitosis by the chaperone complex BAG3-HSPB8 and p62/SQSTM1
Author: Josée N. Lavoie