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Special Issue "Space Omics: Adaptive Gene Expression Changes after Exposure to Spaceflight and Simulated Extraterrestrial Environments"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editor

Dr. Raúl Herranz
E-Mail Website
Guest Editor
PCNPµG Lab (Plant Cell Nucleolus, Proliferation and Microgravity), Centro de Investigaciones Biológicas Margarita Salas (CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain
Interests: Gene redundancy (nucleolin mutants) contribution to suboptimal environments adaptation; altered gravity/radiation simulation & hardware; Spaceflight countermeasures (light, sucrose…)

Special Issue Information

Dear Colleagues,

In recent years, multiple model systems, including for humans, have been exposed to microgravity environments, either real (spaceflight) or simulated. Transcriptomic studies, using microarray or, more recently, sequencing (RNAseq) techniques, are by far the most frequently performed. An important effort for data sharing and harmonization has been undertaken by the project called GeneLab, under the leadership of NASA and the participation of laboratories from different countries. GeneLab organizes datasets in the Data Repository, analyses data using the Analysis Platform, and creates collaborative projects using the Collaborative Workspace.  NASA GeneLab is organized into different analysis working groups (AWGs) supported internationally by other consortiums, such as ISSOP (https://issop.space/) and the Space Omics Topical Team funded by ESA. 

Recent reviews, with important contributions from European scientists (at The Biology of Spaceflight compendium at Cell), have been presented to the scientific community regarding the current opportunities for space-omics research that discuss how to give space biology research the opportunity to meet molecular biology gold standards. This Special Issue aims to go further into describing a subtle, but general, stress response, usually linked to mitochondrial function, as a common response observed across all kingdoms of life so far, usually observed in synergy with the molecular level adaptation to suboptimal environments, such as those observed in spaceflight and microgravity simulation experiments. State of the art multi-omics-based manuscripts are welcome, with a particular emphasis on describing past, present, and future contributions of European molecular biology scientists to the international landscape in space omics research.

Dr. Raúl Herranz on behalf of the Space Omics Topical Team core members

Dr. Raúl Herranz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • space biology
  • system biology
  • multi-omics
  • spatial transcriptomics
  • bioinformatics
  • astronaut health monitoring
  • life support and model systems
  • microgravity
  • radiation
  • spaceflight hardware

Published Papers

This special issue is now open for submission.
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