Special Issue "Molecular Biology of Spermatozoa"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 April 2019).
Interests: flow cytometry applied to sperm analysis; redox regulation of sperm function; cryopreservation; impact of sperm in early embryo
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The spermatozoon is a very special cell; it is generated in the male reproductive tract, and has to travel to the female reproductive tract, of another individual, to fertilize an egg. This amazing journey, however, has to be able to respond and adapt to dramatically changing environments. The last decade has witnessed huge advances in the understanding of the molecular biology of this particular cell; these findings have provided new clues to understand male infertility and the impact of reproductive technologies in sperm function. Thus, empirical approaches for sperm conservation are being substituted by approaches based in translational research. As a transcriptionally-silent cell, spermatozoa largely depend on post-translational modifications of proteins to regulate their functions; among these regulatory mechanisms, redox regulation plays a relevant role, and deregulation of redox homeostasis is behind male factor infertility. With the incorporation of “omics”, lipidomics, epigenomics proteomics, and metabolomics to the study of the spermatozoa, the knowledge of sperm function has increased significantly in the last decade; developments in image analysis and advanced flow cytometry have also significantly contributed to this advance.
Prof. Fernando Juan Peña Vega
Manuscript Submission Information
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- flow cytometry
- redox regulation