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The Role of Stem Cells in Multiple Sclerosis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 3829

Special Issue Editor


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Guest Editor
Hadassah-Hebrew University Medical Center
Interests: Stem Cells Therapy; Multiple Sclerosis; Regenerative Medicine; Neuroimmunology

Special Issue Information

Dear Colleagues,

Multiple sclerosis (MS) is a chronic disease that causes issues with vision, balance, coordination, muscle control, and other basic body functions. Multiple sclerosis (MS) can affect the brain, spinal cord, and optic nerves. The implication of stem cells of different types as a therapeutic treatment option for MS was one of the hot spots in neurodegenerative diseases research in the last decade. Nowadays, several clinical trials—some of them in advanced phases —are ongoing, and encouraging data have been unveiled. This Special Issue of the International Journal of Molecular Sciences titled “The Role of Stem Cells in Multiple Sclerosis” will focus on the therapeutic potential of stem cells in multiple sclerosis. Authors are invited to submit manuscripts that study or review the mechanism and mode of action of stem cells in MS. Pure clinical studies will not be suitable for this Special Issue, but clinical submissions with bimolecular experiments are welcomed.

Dr. Ibrahim Kassis
Guest Editor

Manuscript Submission Information

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Keywords

  • Neuroprotection
  • Immunomodulation
  • Remyelination
  • Neurogeneration
  • Exosomes
  • Delivery regimes

Published Papers (1 paper)

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Research

16 pages, 3143 KiB  
Article
Intranasal Administration of Undifferentiated Oligodendrocyte Lineage Cells as a Potential Approach to Deliver Oligodendrocyte Precursor Cells into Brain
by Ulises Gómez-Pinedo, Jordi A. Matías-Guiu, María Soledad Benito-Martín, Lidia Moreno-Jiménez, Inmaculada Sanclemente-Alamán, Belen Selma-Calvo, Sara Pérez-Suarez, Francisco Sancho-Bielsa, Alejandro Canales-Aguirre, Juan Carlos Mateos-Díaz, Mercedes A. Hernández-Sapiéns, Edwin E. Reza-Zaldívar, Doddy Denise Ojeda-Hernández, Lucía Vidorreta-Ballesteros, Paloma Montero-Escribano and Jorge Matías-Guiu
Int. J. Mol. Sci. 2021, 22(19), 10738; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms221910738 - 04 Oct 2021
Cited by 6 | Viewed by 3190
Abstract
Oligodendrocyte precursor cell (OPC) migration is a mechanism involved in remyelination; these cells migrate from niches in the adult CNS. However, age and disease reduce the pool of OPCs; as a result, the remyelination capacity of the CNS decreases over time. Several experimental [...] Read more.
Oligodendrocyte precursor cell (OPC) migration is a mechanism involved in remyelination; these cells migrate from niches in the adult CNS. However, age and disease reduce the pool of OPCs; as a result, the remyelination capacity of the CNS decreases over time. Several experimental studies have introduced OPCs to the brain via direct injection or intrathecal administration. In this study, we used the nose-to brain pathway to deliver oligodendrocyte lineage cells (human oligodendroglioma (HOG) cells), which behave similarly to OPCs in vitro. To this end, we administered GFP-labelled HOG cells intranasally to experimental animals, which were subsequently euthanised at 30 or 60 days. Our results show that the intranasal route is a viable route to the CNS and that HOG cells administered intranasally migrate preferentially to niches of OPCs (clusters created during embryonic development and adult life). Our study provides evidence, albeit limited, that HOG cells either form clusters or adhere to clusters of OPCs in the brains of experimental animals. Full article
(This article belongs to the Special Issue The Role of Stem Cells in Multiple Sclerosis)
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