Special Issue "Non-classical Steroid Hormone Regulatory Mechanism"
Deadline for manuscript submissions: 31 October 2021.
Interests: biochemistry; analytical chemistry; mass spectrometry; lipidomics; metabolomics; proteomics
Special Issues and Collections in MDPI journals
Interests: renal cell carcinoma; targeted therapy; aldosterone production
The main mechanism of action of steroid hormones is considered to be the endocrine system, in which steroids are synthesized in endocrine organs under the control of the central nervous system and transported throughout the body to act on target cells. Recently, however, mechanisms of action other than the endocrine secretion of steroid hormones have been reported.
Non-systemic steroids are an example of this, and are steroids that act in a paracrine or autocrine manner within a specific organ. Typical examples of non-systemic steroids are neurosteroids, and other steroids are known to be produced and acted upon locally in skeletal muscle, salivary glands, and pancreatic beta cells. There are also increasing reports of intracrine steroids that are synthesized intracellularly and act on their own nuclear receptors. These steroids are essential for specific cellular functions in specific organs, in contrast to glucocorticoids, which have basically common physiological effects throughout the body.
In this special issue, we will focus on the non-classical mechanisms of action of such steroid hormones. We will also focus on cases where the mode of action and the molecular species produced change depending on the disease. Also included in the scope are new techniques to visualize steroid hormones acting on the microenvironment of organs, and structural biology of synthetic enzymes (regioselective control of catalytic activity).
The goal is to deepen the discussion of new mechanisms of steroid production and mode of action, as well as their physiological effects, without being bound by conventional concepts, and aim for further development.
Prof. Dr. Yuki Sugiura
Dr. Koshiro Nishimoto
Manuscript Submission Information
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