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Special Issue "Non-classical Steroid Hormone Regulatory Mechanism"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Prof. Dr. Yuki Sugiura
E-Mail Website
Guest Editor
School of Medicine, Keio University, Tokyo, Japan
Interests: biochemistry; analytical chemistry; mass spectrometry; lipidomics; metabolomics; proteomics
Special Issues and Collections in MDPI journals
Dr. Koshiro Nishimoto
Guest Editor
Department of Uro-Oncology, Saitama Medical University International Medical Center, Saitama, Japan
Interests: renal cell carcinoma; targeted therapy; aldosterone production

Special Issue Information

Dear Colleagues,

The main mechanism of action of steroid hormones is considered to be the endocrine system, in which steroids are synthesized in endocrine organs under the control of the central nervous system and transported throughout the body to act on target cells. Recently, however, mechanisms of action other than the endocrine secretion of steroid hormones have been reported.

Non-systemic steroids are an example of this, and are steroids that act in a paracrine or autocrine manner within a specific organ. Typical examples of non-systemic steroids are neurosteroids, and other steroids are known to be produced and acted upon locally in skeletal muscle, salivary glands, and pancreatic beta cells. There are also increasing reports of intracrine steroids that are synthesized intracellularly and act on their own nuclear receptors. These steroids are essential for specific cellular functions in specific organs, in contrast to glucocorticoids, which have basically common physiological effects throughout the body.

In this special issue, we will focus on the non-classical mechanisms of action of such steroid hormones. We will also focus on cases where the mode of action and the molecular species produced change depending on the disease. Also included in the scope are new techniques to visualize steroid hormones acting on the microenvironment of organs, and structural biology of synthetic enzymes (regioselective control of catalytic activity).

The goal is to deepen the discussion of new mechanisms of steroid production and mode of action, as well as their physiological effects, without being bound by conventional concepts, and aim for further development.

Prof. Dr. Yuki Sugiura
Dr. Koshiro Nishimoto
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

This special issue is now open for submission.
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