Special Issue "Steroids, Central Neurotransmission, Mood, Memory and Mental State"
Deadline for manuscript submissions: closed (31 May 2021).
Interests: neuroendocrinology; neurohormones and neuropeptides; central neural transmission; feedback systems; gonadotropin releasing hormone (GnRH); GnRH self priming effect; pituitary responsiveness to neurohormones; stress and stress effects; corticotropin releasing factor (CRF): PTSD: allostasis; stress as a cause of peptic ulceration; neuropharmacology; psychopharmacology
Special Issues, Collections and Topics in MDPI journals
Steroid hormones secreted by the gonads and adrenal glands affect mood, memory, and mental state in humans. Thus, for example, the increased incidence of mood disorder around the time of menstruation, puerperium, and the menopause has been associated with the coincident fall of plasma estradiol concentrations. Estradiol has also been implicated in and used as adjunct treatment for schizophrenia.
Studies in rodents and humans have shown that estrogen affects central neurotransmission, such as the central serotonin system. In turn, manipulation of central serotonin neurons affects the intracellular mineralocorticoid and glucocorticoid receptors in the hippocampus. These receptors bind cortisol (human) or corticosterone (rodents) secreted by the adrenal cortex at rest in a circadian mode and in larger spurts in response to stress. In addition, steroid hormones also affect synaptogenesis, dendritic branching, myelination and other mechanisms involved in neuroplasticity. Finally, neurosteroids, synthesized within the central nervous system, have proved to be potent allosteric agonists as well as direct activators of GABA-A receptors, thereby providing innovative therapies for epilepsy, brain injury, Fragile X syndrome, and chemical neurotoxicity.
This Special Issue will review the themes outlined above with a focus on novel fundamental and clinical advances.
Prof. Dr. George Fink
Fink G, Sumner BE, Rosie R, Grace O, Quinn JP. Estrogen control of central neurotransmission: effect on mood, mental state, and memory. Cell Mol Neurobiol. 1996 Jun;16(3):325-44. Review
Fink G, Sumner BE, McQueen JK, Wilson H, Rosie R. Sex steroid control of mood, mental state and memory. Clin Exp Pharmacol Physiol. 1998 Oct;25(10):764-75. Review.
Fink G, Sumner B, Rosie R, Wilson H, McQueen J. Androgen actions on central serotonin neurotransmission: relevance for mood, mental state and memory. Behav Brain Res. 1999 Nov 1;105(1):53-68. Review.
Sumner BE, Grant KE, Rosie R, Hegele-Hartung Ch, Fritzemeier KH, Fink G. Raloxifene blocks estradiol induction of the serotonin transporter and 5-hydroxytryptamine2A receptor in female rat brain. Neurosci Lett. 2007 Apr 24;417(1):95-9. Epub 2007 Feb 15.
Moses-Kolko EL1, Berga SL, Greer PJ, Smith G, Cidis Meltzer C, Drevets WC. Widespread increases of cortical serotonin type 2A receptor availability after hormone therapy in euthymic postmenopausal women. Fertil Steril. 2003 Sep;80(3):554-9.
Kulkarni J, Butler S, Riecher-Rössler A. Estrogens and SERMS as adjunctive treatments for schizophrenia. Front Neuroendocrinol. 2019 Apr;53:100743. doi:10.1016/j.yfrne.2019.03.002. Epub 2019 Mar 25.
Seckl JR, Dickson KL, Fink G. Central 5,7-dihydroxytryptamine lesions decrease hippocampal glucocorticoid and mineralocorticoid receptor messenger ribonucleic Acid expression. J Neuroendocrinol. 1990 Dec 1;2(6):911-6. doi: 10.1111/j.1365-2826.1990.tb00659.x.
Reddy DS, Estes WA. Clinical Potential of Neurosteroids for CNS Disorders. Trends Pharmacol Sci. 2016 Jul;37(7):543-561. doi: 10.1016/j.tips.2016.04.003. Epub 2016 May 5.
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.