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Special Issue "Steroids and the Nervous System 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 20 February 2022.

Special Issue Editor

Prof. Dr. George Fink
E-Mail Website
Guest Editor
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia
Interests: neuroendocrinology; neurohormones and neuropeptides; central neural transmission; feedback systems; gonadotropin releasing hormone (GnRH); GnRH self priming effect; pituitary responsiveness to neurohormones; stress and stress effects; corticotropin releasing factor (CRF): PTSD: allostasis; stress as a cause of peptic ulceration; neuropharmacology; psychopharmacology
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Special Issue Information

Dear Colleagues,

Steroids have pleiotropic effects on the nervous system (NS) throughout the lifespan. The NS is both a target and a site of synthesis and metabolism of steroids. Steroid concentrations in the NS depend both on systemic intake and local synthesis. It is now well established that the NS is able to synthesize progesterone, testosterone, and estradiol from cholesterol. In addition, steroids can be metabolized in the NS, and the resulting metabolites can be active agents In different models of NS lesion and neurodegenerative diseases, changes in the local endogenous steroid levels have been observed, suggesting that steroids have an important role in pathophysiological conditions. In addition, several pharmacological studies have demonstrated the therapeutic potential of estrogens, progestagens, and androgens.

This Special Issue “Steroids and the Nervous System 2.0” will compile reviews that address various aspects of the relationships between steroids and the NS, including synthesis, metabolism, regulation, and effects. Special emphasis will be on neurosteroids, neuroactive steroids, and the effects of steroids on brain development and sexual differentiation, neuroprotection, neuroinflammation, myelination, synaptic modulation, memory, and behavior. Reviews on the therapeutic potential of steroids for NS injuries and disorders are also welcome.

Prof. Dr. George Fink
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Steroids
  • Neurosteroids
  • Neuroactive steroids
  • Neuroprotection
  • Myelination
  • Neuroinflammation
  • Sexual differentiation
  • Synaptic modulation
  • Memory

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Published Papers

This special issue is now open for submission.
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