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Molecular Dynamics at Synapses
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Molecular Dynamics at Synapses

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 2764

Special Issue Editor

Dr. Julie Perroy

E-Mail Website
Guest Editor
IGF, University of Montpellier, CNRS, INSERM, 34094 Montpellier, France
Interests: synapse; protein-protein interaction; glutame receptosome; synaptic transmission; cell signaling; plasticity; neuronal networks; autism spectrum disorder
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is devoted to Synaptic Transmission and Protein Interaction.

Synaptic transmission between two neurons includes all the molecular processes allowing the release of neurotransmitters by the presynaptic element, the stimulation of post-synaptic receptors, and the initiation of signaling pathways to transmit the activation of the post-synaptic element. All these molecular mechanisms rely on the ability of proteins to interact, to form functional protein complexes. Protein–protein interactions within these complexes are regulated by environmental stimuli that multiply the number of functional signaling platforms generated from a limited number of proteins, which in turn finely control synaptic transmission. This Special Issue aims to bring together recent advances in our understanding of the dynamics and fundamental roles of protein–protein interactions in synaptic transmission.

Articles offering innovative insights into the multifaceted functions of proteins depending on their interactions are welcome. This Special Issue may include but is not limited to: original research articles focusing on nanodomain organization (receptors multimerization, scaffold interactions, signaling cascades, protein interactomes, etc.), dynamics of protein–protein interaction, further characterization of functional signaling platforms, studies using protein–protein interactions as therapeutic targets, and review articles which summarize and highlight recent advances in the field.

Dr. Julie Perroy
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • synapse
  • protein-protein interaction
  • nanodomain
  • receptosome
  • scaffold complexes
  • synaptic transmission
  • cell signaling
  • interactome

Published Papers (2 papers)

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Research

13 pages, 4446 KiB  
Article
Somatosensory-Evoked Early Sharp Waves in the Neonatal Rat Hippocampus
by Azat Gainutdinov, Dmitrii Shipkov, Mikhail Sintsov, Lorenzo Fabrizi, Azat Nasretdinov, Roustem Khazipov and Guzel Valeeva
Int. J. Mol. Sci. 2023, 24(10), 8721; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms24108721 - 13 May 2023
Cited by 1 | Viewed by 1125
Abstract
The developing entorhinal–hippocampal system is embedded within a large-scale bottom-up network, where spontaneous myoclonic movements, presumably via somatosensory feedback, trigger hippocampal early sharp waves (eSPWs). The hypothesis, that somatosensory feedback links myoclonic movements with eSPWs, implies that direct somatosensory stimulation should also be [...] Read more.
The developing entorhinal–hippocampal system is embedded within a large-scale bottom-up network, where spontaneous myoclonic movements, presumably via somatosensory feedback, trigger hippocampal early sharp waves (eSPWs). The hypothesis, that somatosensory feedback links myoclonic movements with eSPWs, implies that direct somatosensory stimulation should also be capable of evoking eSPWs. In this study, we examined hippocampal responses to electrical stimulation of the somatosensory periphery in urethane-anesthetized, immobilized neonatal rat pups using silicone probe recordings. We found that somatosensory stimulation in ~33% of the trials evoked local field potential (LFP) and multiple unit activity (MUA) responses identical to spontaneous eSPWs. The somatosensory-evoked eSPWs were delayed from the stimulus, on average, by 188 ms. Both spontaneous and somatosensory-evoked eSPWs (i) had similar amplitude of ~0.5 mV and half-duration of ~40 ms, (ii) had similar current-source density (CSD) profiles, with current sinks in CA1 strata radiatum, lacunosum-moleculare and DG molecular layer and (iii) were associated with MUA increase in CA1 and DG. Our results indicate that eSPWs can be triggered by direct somatosensory stimulations and support the hypothesis that sensory feedback from movements is involved in the association of eSPWs with myoclonic movements in neonatal rats. Full article
(This article belongs to the Special Issue Molecular Dynamics at Synapses)
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18 pages, 3921 KiB  
Article
Hyperpolarization Induced by Lipopolysaccharides but Not by Chloroform Is Inhibited by Doxapram, an Inhibitor of Two-P-Domain K+ Channel (K2P)
by Robin L. Cooper and Rebecca M. Krall
Int. J. Mol. Sci. 2022, 23(24), 15787; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms232415787 - 13 Dec 2022
Cited by 4 | Viewed by 1267
Abstract
Bacterial septicemia is commonly induced by Gram-negative bacteria. The immune response is triggered in part by the secretion of bacterial endotoxin lipopolysaccharide (LPS). LPS induces the subsequent release of inflammatory cytokines which can result in pathological conditions. There is no known blocker to [...] Read more.
Bacterial septicemia is commonly induced by Gram-negative bacteria. The immune response is triggered in part by the secretion of bacterial endotoxin lipopolysaccharide (LPS). LPS induces the subsequent release of inflammatory cytokines which can result in pathological conditions. There is no known blocker to the receptors of LPS. The Drosophila larval muscle is an amendable model to rapidly screen various compounds that affect membrane potential and synaptic transmission such as LPS. LPS induces a rapid hyperpolarization in the body wall muscles and depolarization of motor neurons. These actions are blocked by the compound doxapram (10 mM), which is known to inhibit a subtype of the two-P-domain K+ channel (K2P channels). However, the K2P channel blocker PK-THPP had no effect on the Drosophila larval muscle at 1 and 10 mM. These channels are activated by chloroform, which also induces a rapid hyperpolarization of these muscles, but the channels are not blocked by doxapram. Likewise, chloroform does not block the depolarization induced by doxapram. LPS blocks the postsynaptic glutamate receptors on Drosophila muscle. Pre-exposure to doxapram reduces the LPS block of these ionotropic glutamate receptors. Given that the larval Drosophila body wall muscles are depolarized by doxapram and hyperpolarized by chloroform, they offer a model to begin pharmacological profiling of the K2P subtype channels with the potential of identifying blockers for the receptors to mitigate the actions of the Gram-negative endotoxin LPS. Full article
(This article belongs to the Special Issue Molecular Dynamics at Synapses)
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