Special Issue "Alpha-Synuclein in Neurodegeneration"
Deadline for manuscript submissions: 31 May 2021.
Interests: Parkinson's disease; multiple system atrophy; dementia with Lewy bodies; alpha-synuclein; small ubiquitin-like modifier (SUMO); metallothionein; neuroinflammation; calcium; copper; autophagy
Interests: proteon physics; protein folding; protein structure; protein function; protein misfolding; protein aggregation; intrinsically disordered proteins; proteinopathies; proteinaceous membrane-less organelles; liquid–liquid phase transitions
Special Issues and Collections in MDPI journals
Special Issue in International Journal of Molecular Sciences: Intrinsically Disordered Proteins in the Norm and Pathology: In-Silico Perspective
Special Issue in Biomolecules: Intrinsically Disordered Proteins and Chronic Diseases
Special Issue in Biomolecules: Calcium Binding Proteins: Structure, Properties, Functions
Special Issue in Biomolecules: Biomolecules: Insights from Single Molecule, Single Cell, and Systems Biology Perspectives
Special Issue in Biomolecules: Computational Perspectives on Intrinsic Disorder-Based Functionality
Special Issue in Biomolecules: Biomolecular Engineering for Biomedical Applications—Selected papers from NanoBio&Med 2018
Topical Collection in International Journal of Molecular Sciences: Feature Papers in Molecular Biophysics
Special Issue in Biomolecules: 2019 Feature Papers by Biomolecules’ Editorial Board Members
Special Issue in Biomolecules: Celebrating the First Impact Factor of Biomolecules
Topical Collection in Biomolecules: Intrinsically Disordered Proteins
Special Issue in Biomolecules: Yersinia pestis Biomolecules
Special Issue in Biomolecules: 2020 Feature Papers by Biomolecules’ Editorial Board Members
Special Issue in International Journal of Molecular Sciences: It’s a Kind of Magic: Biological Liquid-Liquid Phase Separation, Biomolecular Condensates, and Membrane-less Organelles
Special Issue in Biomolecules: 10th Anniversary of Biomolecules—Recent Advances in Understanding of Molecular Pathology and Therapeutics of Cancer
Special Issue in Biophysica: Role of Water in Biological Systems
Special Issue in Biomolecules: Selected Papers from the 1st International Electronic Conference on Biomolecules
α-Synuclein plays a pivotal role in the development of multiple neurodegenerative diseases that are known collectively as synucleinopathies and include Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy. For many years, research has focused on the formation of intracellular aggregates of protein as the principal causative link to neurodegeneration. Recent studies have revealed many diverse intra- and extracellular neurotoxic interactions, encompassing imbalance in proteostatic systems, metal ion dyshomeostasis, liquid–liquid phase separation, secretory pathway, and mitochondrial dynamics. Although α-synuclein is expressed in multiple different cell types throughout the body, the normal functions of the protein at the neuronal pre-synapse regulating neurotransmitter vesicle trafficking have received much attention and no doubt contribute to the loss of function effects. Emerging data also implicate extracellular roles of α-synuclein as a secreted protein or processed peptide in neuroinflammation and by interacting with other disease-linked extracellular proteins, such as tau and Aβ. Central to the normal and pathological activities of α-synuclein is the dynamic nature of the protein that is modulated by calcium-binding, interaction with various partners, and by a variety of post-translational modifications. Self-association of α-synuclein in oligomeric, pre-fibrillar, and fibrillar forms provides platforms for the interaction of α-synuclein with a growing array of proteins, lipids, small molecules, and ions. Altogether, α-synuclein, with its spatiotemporal structural heterogeneity and multifunctionality represents an important example of the protein structure-function continuum concept. The design of novel neuroprotective and ameliorative therapies requires a comprehensive understanding of the α-synuclein interactome network in order to tackle both the initiation and progression of disease processes. In this Special Issue, we hope that investigators will join together in exploring and integrating the current knowledge to stimulate future inquiry towards the end of disease mitigation.
Dr. Dean L. Pountney
Dr. Vladimir N. Uversky
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Parkinson’s disease
- Dementia with Lewy bodies
- Multiple system atrophy
- Protein misfolding
- Disordered proteins