Special Issue "T-Regulatory Cells in Autoimmunity and Transplantation"
Deadline for manuscript submissions: 31 December 2021.
Interests: Immunology; chronic inflammatory diseases; autoimmunity; adaptive immunity; antigen presentation; antimicrobial peptides; antimicrobial chemokines; B Cells; antibodies
Special Issues, Collections and Topics in MDPI journals
Special Issue in International Journal of Molecular Sciences: Antimicrobial Peptides and Antimicrobial Chemokines
Special Issue in International Journal of Molecular Sciences: Antimicrobial Peptides and Antimicrobial Chemokines 2.0
Autoimmune diseases are non-communicable diseases characterized by self-tolerance breakdown. Some of these diseases are mainly classified as autoantibody-driven diseases (for instance systemic lupus erythematosus), however, others such as psoriasis, are T-cell mediated. Alloreactivity is a phenomenon induced by organ and tissue transplantation, in which the host’s adaptive immune response is activated by alloantigens present on the transplant. In both situations, autoimmunity and alloreactivity, it is necessary to block excessive immune responses by immune suppressant treatments. Regulatory T-cells are pivotal to maintain immune homeostasis and prevent autoreactive responses activation by suppressing T and/or B-cell responses directed towards self-antigens. However, the same cells also regulate allotransplant tolerance. T-regulatory cell-based adoptive therapies have been tried in both autoimmunity and transplantation fields. In both situations, sterile inflammation is present.
This Special Issue calls for original research articles and reviews on the importance of T-regulatory cells, and the molecular mechanisms underlying their actions, in autoreactivity and transplantation. Appropriate animal studies on autoimmune disease and transplantation models are also of interest. This Special Issue points to bring together the knowledge in two scientific settings that tend to be sectoral but address exactly the same issue: suppress deleterious immune responses and consequent tissue/organ damage. We strongly believe that knowledge, experience accumulated in in vivo models and clinical achievements should be shared between these two fields of medicine and research to improve patients’ lives.
Dr. Loredana Frasca
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- T-regulatory cells
- Adaptive immunity
- Antigen presentation
- Therapy targets
- Immune regulation
- T-regs based immune-therapy