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Dr. Hiroyuki Mori

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Guest Editor

Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA
Interests: Type 2 diabetes; Obesity; metabolic dysfunction; Obesity related

Special Issue Information

Dear Colleagues,

Worldwide obesity has nearly tripled since the time of the Green Revolution that boosted the production of grains approximately 2.5 times. Obesity reduces not only life expectancy but also Healthy Life-Years due to its number of serious complications including type 2 diabetes, cardiovascular disease, hypertension, certain cancers, and stroke. Thus, obesity and related diseases create burdensome health care and other economic costs for society. Growing obesity is a multi-faceted problem that will require many levels of public action. Our responsibility as members of the scientific community is to uncover novel mechanisms underlying the development of obesity and type 2 diabetes, and to develop therapeutic strategies to prevent these diseases for the health and welfare of society. For submission to this Issue, both original research articles and comprehensive review papers are welcomed.

Dr. Hiroyuki Mori
Guest Editor

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Keywords

Obesity
Type 2 diabetes
Insulin resistance
Obesity associated metabolic dysfunction
Obesity related diseases
Energy balance

Published Papers (1 paper)

Review

28 pages, 846 KiB

Open AccessReview

Insects as a New Complex Model in Hormonal Basis of Obesity

by Karolina Walkowiak-Nowicka, Szymon Chowański, Arkadiusz Urbański and Paweł Marciniak

Int. J. Mol. Sci. 2021, 22(20), 11066; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222011066 - 14 Oct 2021

Cited by 2 | Viewed by 2804

Abstract

Nowadays, one of the biggest problems in healthcare is an obesity epidemic. Consumption of cheap and low-quality energy-rich diets, low physical activity, and sedentary work favor an increase in the number of obesity cases within many populations/nations. This is a burden on society, public health, and the economy with many deleterious consequences. Thus, studies concerning this disorder are extremely needed, including searching for new, effective, and fitting models. Obesity may be related, among other factors, to disrupting adipocytes activity, disturbance of metabolic homeostasis, dysregulation of hormonal balance, cardiovascular problems, or disorders in nutrition which may lead to death. Because of the high complexity of obesity, it is not easy to find an ideal model for its studies which will be suitable for genetic and physiological analysis including specification of different compounds’ (hormones, neuropeptides) functions, as well as for signaling pathways analysis. In recent times, in search of new models for human diseases there has been more and more attention paid to insects, especially in neuro-endocrine regulation. It seems that this group of animals might also be a new model for human obesity. There are many arguments that insects are a good, multidirectional, and complex model for this disease. For example, insect models can have similar conservative signaling pathways (e.g., JAK-STAT signaling pathway), the presence of similar hormonal axis (e.g., brain–gut axis), or occurrence of structural and functional homologues between neuropeptides (e.g., neuropeptide F and human neuropeptide Y, insulin-like peptides, and human insulin) compared to humans. Here we give a hint to use insects as a model for obesity that can be used in multiple ways: as a source of genetic and peptidomic data about etiology and development correlated with obesity occurrence as well as a model for novel hormonal-based drug activity and their impact on mechanism of disease occurrence. Full article

(This article belongs to the Special Issue Molecular Regulators In Obesity and Diabetes)

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