Special Issue "TRPA1 Channel"
Deadline for manuscript submissions: closed (31 January 2021).
Interests: thermosensitive TRP channels; membrane biophysics; electrophysiology; nociception; mathematical modeling
Interests: TRP channel chemosensitivity; TRP channel thermosensitivity; TRP channel mechanosensitivity; TRP secretory cell signaling; TRP pharmacology; nociception; pain
The transient receptor potential ankyrin 1 receptor (TRPA1) is a cation channel expressed in dorsal root, trigeminal, and visceral primary sensory neurons, but also in various non-neuronal cells such as lung fibroblast and epithelial cells, smooth muscle cells, hair cells, keratinocytes, odontoblasts, astroglia, Schwann cells, and arterial vessels. There, TRPA1 acts as a multipurpose sensor of harmful signals, being activated by a wide range of chemical and physical stimuli. Accumulating evidence links the physiological functions of TRPA1 to nociception, inflammation, temperature perception, mechanosensation, insulin secretion, itching, respiratory functions, regulation of the cardiovascular system, and also the homeostatic balance between the immune and nociceptive systems. Given the wide expression pattern of TRPA1, a precise knowledge of the channel function is essential before it can be considered a potential target for the development of new, safe, and clinically relevant drugs.
Until very recently, information about the three-dimensional structure of TRPA1 has lagged behind information obtained from mutational and functional studies. At the break of 2019/2020, high-resolution structures of TRPA1 in different conformations have been published as a result of the recent “resolution revolution” in single-particle cryo-electron microscopy. Obviously, these new findings will further allow the rationalization of structure–activity studies, understanding the functional impact of TRPA1 genetic polymorphisms, and, perhaps more importantly, rational screening of novel modulators as potential selective therapeutic agents.
This Special Issue will provide a platform for original research papers and reviews describing the most recent findings in the TRPA1 field, covering any topics related to the biophysics, structure, pharmacology, physiological/pathophysiological roles, new molecular-based therapeutic strategies, and human genetic association studies.
Dr. Viktorie Vlachova
Prof. Peter M. Zygmunt
Manuscript Submission Information
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- Transient receptor potential ankyrin subtype 1
- Sensory neuron
- Thermosensitive TRP channel
- Mechanosensitive TRP channel