Special Issue "TRPM Channels"
Deadline for manuscript submissions: 1 July 2021.
The Melastatin (TRPM) subfamily of the fascinating Transient Receptor Potential (TRP) ion channels forms a structurally and functionally diverse group of eight close relatives of cation channels. They are characterized by diverse gating stimuli, including changes in environmental temperature, osmolarity, ADP-ribose or intra- and extracellular ions. They function as thermosensors, gatekeepers of cellular ion homeostasis, or regulators of secretory functions, inflammatory processes and redox signaling. Some of them possess a unique double identity, simultaneously functioning as ion channels and enzymes (“chanzymes”).
TRPM channels are widely studied in the sensory system, in various immune cells, as well as in epithelial barriers, but they are virtually expressed by every cell-types of the human body. Intense research of the past two decades advanced a lot in their understanding and in the last years we gained a deeper insight into their molecular structure. However, in spite of our rapidly growing knowledge, there are still several mysteries in this intriguing group of ion channels. This Special Issue provides a forum for summarizing our current knowledge and presenting selected chapters of actual research targeting any aspect of these exciting members of TRP channels.
Dr. Balazs Istvan Toth
Prof. Thomas Voets
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