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Special Issue "Frontiers in Chemical Tools for Targeted Cancer Therapy"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Dr. Alexander Shtil
E-Mail Website
Guest Editor
Blokhin Cancer Center and Institute of Gene Biology, Russian Academy of Sciences, 24 Kashirskoye shosse, 115478 Moscow, Russia
Interests: intracellular signaling; cancer; chemotherapy; molecular targets; drug design; computational chemistry

Special Issue Information

Dear Colleagues,

Intracellular signaling, a language understandable by biological structures, is an astonishingly smart system of cues and responses. Throughout the entire life span this language remains the major source of communication between the organism and the surrounding milieu, between the cells within the tissue, and between the molecules in the cells. Moreover, disease as a sustained deregulation of signaling can be considered a misspelling and misunderstanding.

To expand our knowledge about signaling the researchers need instruments that selectively interact with individual cellular targets. Calling these instruments the exogenous cues we expect the specific cellular replies. Therapeutically speaking, our instruments represent the mechanism-based drug candidates.

I am pleased to propose a Special Issue entitled "Chemical Tools for Targeted Cancer Therapy". I foresee this volume as a compendium of novel trends in chemistry and biology of antitumor agents (mostly, but not exclusively, low molecular weight compounds). New and established targets will be evaluated from the perspective of engagement by chemical instruments. Therefore studies of in silico and experimental interactions of drug candidates with tentative or established targets are welcome. Most importantly, what are the results of these interactions at the subcellular and cellular levels and in the clinic? Finally, of the exceptional value is critical re-evaluation of targeted anticancer treatment via dissection of this concept’s pros and contras.

Dr. Alexander Shtil
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • intracellular signaling
  • cancer
  • chemotherapy
  • molecular targets
  • drug design
  • computational chemistry

Published Papers

This special issue is now open for submission.
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