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Special Issue "Molecular Mechanism of Thermoregulation in Ectotherms"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 July 2021.

Special Issue Editor

Prof. Dr. Sebastian Boltana
Guest Editor
Biotechnology Center, Facultad de Ciencias Naturales y Oceanogr√°ficas, Universidad de Concepcion, Concepcion, Chile
Interests: temperature; fever; thermoregulation; climate change; methylation; inflammatory reflex; cholinergic receptor; thermal perception

Special Issue Information

Dear Colleagues,

Many vertebrates regulate their body temperature in response to thermal variability of the environment. Endotherms maintain relatively stable body temperatures by adjusting metabolic heat production in response to varying environmental heat loads. Although most ectotherms do not display adaptive thermogenesis, they do adapt the cellular machinery and behavioral mechanism to compensate for environmental temperature variation. In general, the maintenance of the core body temperature is a critical brain function accomplished by the central neural network. This orchestrates a complex behavioral and autonomic repertoire in response to environmental temperature challenges or in support of immune responses (e.g., fever). In general, some components of the thermoregulatory systems in endotherms and ectotherms have been evolutionarily conserved. For example, it has been shown that environmental temperature is detected by the primary afferents of the somatosensory neurons in the skin, which express a set of ion channels (TRP receptor family) to detect particular temperatures. Thermal sensory (afferent) information is relayed to the brain (hypothalamus), which initiates a sympathetic efferent response. In recent years, several studies have revealed a number of receptor ion channels that mediate the perception of several temperature ranges. Most of the knowledge about thermoregulation and thermoperception corresponds to mammals and model animals such as rodents, mice and rats; however, the underlying molecular mechanism of the thermoregulation in ectotherms remains unknown. The present Special Issue will allow us to gain an understanding of the anatomical, thermoreceptor and functional relationships within the molecular network that control the thermoregulation in ectotherms. Delineating the molecular circuit mechanism underlying the thermoregulation provides us with a platform for exploring its functional organization, elucidating the molecular underpinnings of its interactions, and discovering novel approaches to modulating body temperature, as well as being able to understand how the ectotherms may cope with climate change.

Prof. Dr. Sebastian Boltana
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • temperature
  • homeostasis
  • ectotherms
  • thermoregulation
  • thermal perception
  • TRP channels
  • sensory neuron
  • fever

Published Papers

This special issue is now open for submission.
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