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Neurobiology of Traumatic Memory: From Molecules to Function

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 2724

Special Issue Editor

Laboratorio di Neurofisiologia Sperimentale e del Comportamento, IRCCS Fondazione Santa Lucia c/o CERC, 00143 Rome, Italy
Interests: endocannabinoid system; spatial learning; hippocampus; dorsal striatum; amygdala; circular hole board; am251; mice

Special Issue Information

Dear Colleagues,

After experiencing traumatic conditions, an aberrant fear learning process and its persistence may lead to the development of a highly debilitating psychiatric disorder, such as post-traumatic stress disorder. The acquisition of fear associative memory requires brain processes of coordinated neural activity and trafficking of specific molecules within the amygdala, prefrontal cortex, hippocampus, thalamus and brainstem, and hubs of fear matrix. After fear consolidation, a suppression of fear memory in the absence of danger is crucial to permit adaptive coping behavior. The robust correspondence between the brain networks encompassing cortical and subcortical hubs as well as molecular factors involved in fear processing in humans and in other species emphasizes the crucial utility of comparing the modulation of brain circuitry and molecules in humans and animals, to fill the gap into the comprehension of fear mechanisms and the development of treatments for trauma-related disorders. The present Special Issue is aimed at providing innovative preclinical and experimental research and a comprehensive description of the literature regarding the neurobiology of traumatic memory, taking into account a range of topics, from molecules to function and their peculiar interaction within the specific processing of trauma.

Dr. Daniela Laricchiuta
Guest Editor

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Published Papers (1 paper)

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Review

15 pages, 633 KiB  
Review
Neurogenic Interventions for Fear Memory via Modulation of the Hippocampal Function and Neural Circuits
by Hee Ra Park, Mudan Cai and Eun Jin Yang
Int. J. Mol. Sci. 2022, 23(7), 3582; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23073582 - 25 Mar 2022
Cited by 6 | Viewed by 2398
Abstract
Fear memory helps animals and humans avoid harm from certain stimuli and coordinate adaptive behavior. However, excessive consolidation of fear memory, caused by the dysfunction of cellular mechanisms and neural circuits in the brain, is responsible for post-traumatic stress disorder and anxiety-related disorders. [...] Read more.
Fear memory helps animals and humans avoid harm from certain stimuli and coordinate adaptive behavior. However, excessive consolidation of fear memory, caused by the dysfunction of cellular mechanisms and neural circuits in the brain, is responsible for post-traumatic stress disorder and anxiety-related disorders. Dysregulation of specific brain regions and neural circuits, particularly the hippocampus, amygdala, and medial prefrontal cortex, have been demonstrated in patients with these disorders. These regions are involved in learning, memory, consolidation, and extinction. These are also the brain regions where new neurons are generated and are crucial for memory formation and integration. Therefore, these three brain regions and neural circuits have contributed greatly to studies on neural plasticity and structural remodeling in patients with psychiatric disorders. In this review, we provide an understanding of fear memory and its underlying cellular mechanisms and describe how neural circuits are involved in fear memory. Additionally, we discuss therapeutic interventions for these disorders based on their proneurogenic efficacy and the neural circuits involved in fear memory. Full article
(This article belongs to the Special Issue Neurobiology of Traumatic Memory: From Molecules to Function)
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