Shedding New Light into Ubiquitin and Ubiquitin-Like Proteins: Messages for Proteostasis and Organismal Homeostasis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 2429
Special Issue Editor
Interests: proteome complexity; pathogenesis of cancer; post-translational modifications; ubiquitination; immune diseases; neurodegenerative disorders
Special Issue Information
Dear Colleagues,
Cells have evolved stringent protein quality and quantity-control equipment for maintenance of proteostasis and subsequent organismal homeostasis. Proteostasis is ensured by a complex network of mechanisms by which protein folding, concentration, localization and association with other molecules can be monitored from the synthesis to degradation of proteins. Since the discovery of ubiquitin as a ubiquitous protein that is conjugated to other proteins in 1975, several protein families referred to as ubiquitin-like proteins, including ISG15, SUMO, NEDD8, FAT10, UFM1, ATG8, and ATG12 have been discovered, which are structurally as well as evolutionarily related to ubiquitin. Given that a large variety of code generated via post-translational modifications (PTMs) by ubiquitin and ubiquitin-like proteins have pivotal roles in the regulation of various cellular activities, involving protein stability, intracellular trafficking, cell cycle, stress responses, and immune modulation, precisely fine-tuned PTMs by ubiquitin and ubiquitin-like proteins are essential to ensure accurate cellular processes and organismal homeostasis. Moreover, a failure in the adequate maintenance of PTMs is closely associated with various human diseases such as cancer, metabolic diseases, neurological disorders and immune diseases, implicating the importance of sophisticated and stringent mechanisms of PTM regulation.
In this Special Issue of International Journal of Molecular Sciences, we would like to invite contributions addressing the basic biology and properties of ubiquitin and ubiquitin-like proteins but also the multifaceted roles of ubiquitin and ubiquitin-like proteins, with an emphasis on their implications in physiology and pathophysiology of various human diseases involving infectious diseases, neurological disorders and cancers. We are also willing to consider the potential of therapeutic interventions for targeting ubiquitin and ubiquitin-like proteins and their machineries for disease treatment.
Submissions can either be original research papers or reviews. Your contributions will be highly appreciated.
Prof. Dr. Young Joo Jeon
Guest Editor
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Keywords
- ubiquitin
- ubiquitin-like proteins
- post-translational modifications
- conjugation
- deconjugation
- proteostasis
- ubiquitin-proteasome system
- autophagy
- human diseases
- targeted therapy