Special Issue "Targeting the Untargeted Proteome: From Structure-Based Inhibitor Discovery to Chemical Biology and Beyond"
Deadline for manuscript submissions: 31 May 2021.
Interests: structural biology, protein crystallography, structure-based inhibitor development and chemical biology of signaling pathway, essentially protein kinases
Biologically active small molecules that can modulate protein functions provide a powerful tool in the exploration of biology. During the past decades, advances in structural biology methodologies have accelerated the development of chemical modulators by not only assisting chemistry design but offering insights into their modes of action. Many compounds capable of inducing phenotypic changes at the cellular or even organism levels have expanded the repertoire of biological processes and in some cases opened new chemotherapeutic opportunities for disease treatment. Despite many successes, our understanding of human diseases remains limited in many instances. Unlocking the ‘untargeted’ proteome to expand the proteomic space has been tabled as a new global challenge under the ‘Target 2035’ program. Therefore, we have launched the Special Issue “Targeting the Untargeted Proteome: From Structure-Based Inhibitor Discovery to Chemical Biology and Beyond” of the International Journal of Molecular Sciences for research papers and reviews about structure-based inhibitor development and chemical biology, which elucidate functions as well as potential modulations of the untargeted proteins at molecular levels. In addition, studies on early inhibitor designs, methodologies for unlocking the undruggable proteome, and potential alternative functions of proteins with existing chemical modulators will be considered.Dr. Apirat Chaikuad
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- structure-based inhibitor design
- chemical biology
- untargeted proteins
- undruggable proteome
- chemical probe
- chemical modulators
- target 2035
- small molecule screening
- inhibitor discovery
- protein structures