Special Issue "Structural Variations of the Genome"
Deadline for manuscript submissions: closed (30 September 2021).
The genomes of eukaryotes are being understood in more and more detail due to DNA-directed studies at different levels of resolution. Already, with the help of cytogenetics, first insights into structural genomic variants, such as chromosomal heteromorphims, can be obtained. The underlying copy number variants can be further elucidated by means of molecular cytogenetics, molecular karyotyping, and/or sequencing approaches. Further, epigenetics may play a role in both the structural and flexible adaptations of genomes under specific evolutionary pressures. In the best-studied eukaryotic genome so far, that is, the human one, copy number variants as well as three-dimensional networking of the genome in “topologically associated domains” (TADs) are recognized to be important. Even when it comes to the origins of genetic disorders, underlying point mutations are not so much the only causes to be considered anymore.
For this Special Issue, we look forward to receiving original research manuscripts, as well as methodological and review articles, with a special focus on the structural variability and flexibility of the genome, which can be observable at various levels in different species (e.g., copy number variants of heterochromatic and euchromatic material, mechanisms of genetic silencing, position effects, 3D structure of the nucleus, epigenetic mechanisms). We are confident that the compiling of different aspects of eukaryote genome complexity in one volume will provide an important contribution to molecular genetics and genomics.
Dr. Thomas Liehr
Dr. Martina Rincic
Manuscript Submission Information
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- copy number variants
- gene silencing
- position effects
- topologically associated domains (TADs)
- fragile sites
- chromosomal evolution
- repetitive elements
- chromosomal rearrangements