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Special Issue "Vitamin E: Function and Metabolism"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 March 2022.

Special Issue Editor

Dr. Manfred L. Eggersdorfer
E-Mail Website
Guest Editor
Department of Internal Medicine, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands
Interests: micronutrients; nutrient intake and status; biomarker; impact of inadequate intake on health; healthy ageing

Special Issue Information

Dear Colleagues,

Vitamin E is a fat-soluble vitamin with several forms, but alpha-tocopherol is the only one used by the human body. Its main role is to act as an antioxidant, scavenging loose electrons—so-called “free radicals”—that can damage cells. Free radicals form as a result of normal body processes. They cause damage that shortens the life of your cells. Vitamin E is a powerful antioxidant that may help reduce free radical damage and slow the aging process of cells. Its deficiency is associated with ataxia, neuropathy, anaemia and several other health conditions.

Vitamin E is considered the most important fat-soluble antioxidant of cellular membranes and circulating lipoproteins, with important applications in prevention and adjuvant treatment of some chronic and degenerative diseases, such as atherosclerosis, Alzheimer’s disease, neuroinflammation and neurotoxicity associated with epilepsy. In addition to its antioxidant function, vitamin E and its related long-chain metabolites are PXR agonists with the dimethyl configurations of the chroman ring as the most active ones. PXR is a nuclear receptor involved in the modulation of metabolic enzymes and transporters in the metabolism of xenobiotics and endobiotics such as steroids and β-amyloid peptides that are associated with the pathogenesis of Alzheimer’s disease. These metabolites also exhibit potential anti-inflammatory effects, inhibiting COXs and 5-LOX. 5-LOX is responsible for the production of leukotrienes which are potent proinflammatory mediators involved in DNA oxidative damage, allergic and autoimmune reactions, and several pathophysiological conditions such as cardiovascular and liver diseases, neurodegeneration and cancer.

This Special Issue examines in detail, and provides an update on, the molecular targets, protective effects and modes of action of vitamin E and its metabolites, as well as their roles in prevention and treatment of human diseases both in preclinical animal models and clinical trials.

 

Dr. Manfred Eggersdorfer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Tocopherol status
  • Vitamin E deficiency
  • Vitamin E prevalence
  • Vitamin E status
  • Fat-soluble vitamin
  • Free radicals
  • Metabolites

Published Papers (2 papers)

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Review

Review
Enjoy Carefully: The Multifaceted Role of Vitamin E in Neuro-Nutrition
Int. J. Mol. Sci. 2021, 22(18), 10087; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms221810087 - 18 Sep 2021
Viewed by 442
Abstract
Vitamin E is often associated with health benefits, such as antioxidant, anti-inflammatory and cholesterol-lowering effects. These properties make its supplementation a suitable therapeutic approach in neurodegenerative disorders, for example, Alzheimer’s or Parkinson’s disease. However, trials evaluating the effects of vitamin E supplementation are [...] Read more.
Vitamin E is often associated with health benefits, such as antioxidant, anti-inflammatory and cholesterol-lowering effects. These properties make its supplementation a suitable therapeutic approach in neurodegenerative disorders, for example, Alzheimer’s or Parkinson’s disease. However, trials evaluating the effects of vitamin E supplementation are inconsistent. In randomized controlled trials, the observed associations often cannot be substantiated. This could be due to the wide variety of study designs regarding the dosage and duration of vitamin E supplementation. Furthermore, genetic variants can influence vitamin E uptake and/or metabolism, thereby distorting its overall effect. Recent studies also show adverse effects of vitamin E supplementation regarding Alzheimer’s disease due to the increased synthesis of amyloid β. These diverse effects may underline the inhomogeneous outcomes associated with its supplementation and argue for a more thoughtful usage of vitamin E. Specifically, the genetic and nutritional profile should be taken into consideration to identify suitable candidates who will benefit from supplementation. In this review, we will provide an overview of the current knowledge of vitamin E supplementation in neurodegenerative disease and give an outlook on individualized, sustainable neuro-nutrition, with a focus on vitamin E supplementation. Full article
(This article belongs to the Special Issue Vitamin E: Function and Metabolism)
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Review
Tocopherols and Tocotrienols—Bioactive Dietary Compounds; What Is Certain, What Is Doubt?
Int. J. Mol. Sci. 2021, 22(12), 6222; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22126222 - 09 Jun 2021
Cited by 5 | Viewed by 889
Abstract
Tocopherols and tocotrienols are natural compounds of plant origin, available in the nature. They are supplied in various amounts in a diet, mainly from vegetable oils, some oilseeds, and nuts. The main forms in the diet are α- and γ-tocopherol, due to the [...] Read more.
Tocopherols and tocotrienols are natural compounds of plant origin, available in the nature. They are supplied in various amounts in a diet, mainly from vegetable oils, some oilseeds, and nuts. The main forms in the diet are α- and γ-tocopherol, due to the highest content in food products. Nevertheless, α-tocopherol is the main form of vitamin E with the highest tissue concentration. The α- forms of both tocopherols and tocotrienols are considered as the most metabolically active. Currently, research results indicate also a greater antioxidant potential of tocotrienols than tocopherols. Moreover, the biological role of vitamin E metabolites have received increasing interest. The aim of this review is to update the knowledge of tocopherol and tocotrienol bioactivity, with a particular focus on their bioavailability, distribution, and metabolism determinants in humans. Almost one hundred years after the start of research on α-tocopherol, its biological properties are still under investigation. For several decades, researchers’ interest in the biological importance of other forms of vitamin E has also been growing. Some of the functions, for instance the antioxidant functions of α- and γ-tocopherols, have been confirmed in humans, while others, such as the relationship with metabolic disorders, are still under investigation. Some studies, which analyzed the biological role and mechanisms of tocopherols and tocotrienols over the past few years described new and even unexpected cellular and molecular properties that will be the subject of future research. Full article
(This article belongs to the Special Issue Vitamin E: Function and Metabolism)
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