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Special Issue "Vitamin E: Function and Metabolism"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Dr. Manfred L. Eggersdorfer
E-Mail Website
Guest Editor
Department of Internal Medicine, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands
Interests: micronutrients; nutrient intake and status; biomarker; impact of inadequate intake on health; healthy ageing

Special Issue Information

Dear Colleagues,

Vitamin E is a fat-soluble vitamin with several forms, but alpha-tocopherol is the only one used by the human body. Its main role is to act as an antioxidant, scavenging loose electrons—so-called “free radicals”—that can damage cells. Free radicals form as a result of normal body processes. They cause damage that shortens the life of your cells. Vitamin E is a powerful antioxidant that may help reduce free radical damage and slow the aging process of cells. Its deficiency is associated with ataxia, neuropathy, anaemia and several other health conditions.

Vitamin E is considered the most important fat-soluble antioxidant of cellular membranes and circulating lipoproteins, with important applications in prevention and adjuvant treatment of some chronic and degenerative diseases, such as atherosclerosis, Alzheimer’s disease, neuroinflammation and neurotoxicity associated with epilepsy. In addition to its antioxidant function, vitamin E and its related long-chain metabolites are PXR agonists with the dimethyl configurations of the chroman ring as the most active ones. PXR is a nuclear receptor involved in the modulation of metabolic enzymes and transporters in the metabolism of xenobiotics and endobiotics such as steroids and β-amyloid peptides that are associated with the pathogenesis of Alzheimer’s disease. These metabolites also exhibit potential anti-inflammatory effects, inhibiting COXs and 5-LOX. 5-LOX is responsible for the production of leukotrienes which are potent proinflammatory mediators involved in DNA oxidative damage, allergic and autoimmune reactions, and several pathophysiological conditions such as cardiovascular and liver diseases, neurodegeneration and cancer.

This Special Issue examines in detail, and provides an update on, the molecular targets, protective effects and modes of action of vitamin E and its metabolites, as well as their roles in prevention and treatment of human diseases both in preclinical animal models and clinical trials.


Dr. Manfred Eggersdorfer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Tocopherol status
  • Vitamin E deficiency
  • Vitamin E prevalence
  • Vitamin E status
  • Fat-soluble vitamin
  • Free radicals
  • Metabolites

Published Papers

This special issue is now open for submission.
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