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Special Issue "Bioreductive Activation/Detoxification of Prooxidant Xenobiotics and Drugs 2021"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Role of Xenobiotics".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editor

Prof. Dr. Narimantas K. Cenas
E-Mail Website
Guest Editor
Institute of Biochemistry of Vilnius University, Saulėtekio 7, LT-10257 Vilnius, Lithuania
Interests: flavoenzyme catalysis; quinones; nitroaromatics; aromatic N-oxides; polyphenolic antioxidants; mechanisms of cytotoxicity
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Quinones, nitroaromatic compounds, and aromatic N-oxides represent important groups of anticancer, antimicrobial, and antiparasitic agents used with variable success. Additionally, nitroaromatics comprise an important group of industrial pollutants and are widely used as explosives. Importantly, the therapeutic activity and cytotoxicity or side-action of the above groups of compounds are most frequently attributed to their single- or two-electron reduction, performed mainly by flavoenzymes or low-potential FeS redox proteins. Depending on the reaction mechanism and the presence of reductively activated alkylating or leaving groups, bioreductive events may either confer cytotoxicity to the above compounds by means of oxidative stress or formation of alkylating products or contribute to their detoxification. Interestingly, similar bioreductive events occur at the initial steps of nitroaromatic pollutants’ biodegradation.

The diversification of cancer chemotherapy and tumor imaging methods and the emergence of parasite strains resistant to classical drugs require the permanent synthesis of new representatives of these compounds and studies of their mechanisms of action. The same applies for the design of new methods of biodegradation of prooxidant pollutants.

The aim of this Special Issue is to provide an updated point of view about the enzymatic mechanisms of single- and two-electron reduction of quinones, nitroaromatic compounds, aromatic N-oxides, and other groups of prooxidant compounds, their possible enzymatic targets, their role(s) in compound cytotoxicity or therapeutic activity, and their biodegradation efficiency.

Prof. Dr. Narimantas K. Cenas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • prooxidant xenobiotics and drugs
  • free radicals
  • oxidative stress
  • bioreductive activation and alkylation
  • biodegradation

Published Papers

This special issue is now open for submission.
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