Special Issue "Yeast Cell Signalling Pathways"
Deadline for manuscript submissions: 30 September 2021.
Interests: lipid and energy metabolism; lipid metabolic pathways; interorganelle membrane contact sites; organelle dysfunction in disease; aging; lipid-related diseases; molecular disease mechanisms in lipid disorders
In order to respond to metabolic and environmental cues, cells are equipped with a sophisticated array of receptors and proteins that are able to receive and transduce signals by triggering a chain of events that not only carries the input but also amplifies it though coordinated activation of multiple protein complexes and signaling effectors. The ability to integrate multiple signals into a unified action plan is, by far, one of the most open questions in the field. And, yet, cells aren’t simply targets but also convey messages to other cells both near and far.
A new view of signaling networks as integrative systems is now emerging with the fast-evolving era of ´omics´, that has served as a novel paradigm that has long surpassed the classical single-gene or protein-centric approach common in biological research, providing us with a conceptual view of dynamically exchanging networks of chemical and protein interactions, where concepts of concentration, compartmentalization, and phase transition and diffusion are at the foundation of interconnectivity and high-throughput signaling responses, with compelling beauty and intricacy.
In this Special Issue, we would like to highlight the dynamic nature of yeast signaling transduction with emphasis on (i) challenges on the extent of complexity that underlies biological responses and events, (ii) the specific and non-specific interactions of proteins with lipids and other proteins, (iii) expansive diversity of proteins and interaction/binding motifs and interfaces responsible for transducing signals, (iv) various therapeutic strategies arising from basic and applied research in signal transduction using this model system, and (v) emerging and novel areas in molecular medicine and rational drug design.
Dr. Vitor Teixeira
Manuscript Submission Information
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- signal transduction
- intracellular and intercellular communication
- cell surface receptors
- protein kinases and phosphatases
- transcription factors
- signal networks
- posttranslational modification
- biomedical research