ijms-logo

Journal Browser

Journal Browser

Special Issue "The Role of Fibrinolytic System in Health and Disease"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 28 February 2021.

Special Issue Editor

Prof. Hau C. Kwaan
Website
Guest Editor
Marjorie C. Barnett Professor of Hematology–Oncology, Professor of Medicine, Northwestern University Feinberg School of Medicine, 710 Fairbanks Court, Olson Pavilion, Rm 8258 Chicago, IL 60611, USA
Interests: basic and clinical aspects of thrombosis and hemostasis

Special Issue Information

Dear Colleagues,

The proteolytic enzyme plasmin is the central component of the fibrinolytic system (also known as the plasminogen–plasmin system). Originally thought to be a regulator of fibrin removal, it is now known to be more complex. It consists of several serine proteases and their inhibitors (serpins). These are involved in many physiological functions in the pathogenesis of many diseases, including atherosclerosis, obesity, cancer, immune disorders, neuronal degeneration, trauma, inflammation and aging. Knowledge of their role in cancer enables their use as a prognostic factor. Therapeutic use of various forms of proteases derived from this system has been employed in the form of thrombolytic agents. In addition, small molecules designed to inhibit many of the components of the fibrinolytic system are now available in clinical trials, aimed at the treatment of these various disorders. This remarkable development of our knowledge on fibrinolysis is the theme in this Special Issue of the International Journal of Molecular Sciences.

Prof. Hau C. Kwaan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fibrinolysis
  • plasminogen activators
  • trauma
  • immunity
  • aging

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Review

Open AccessReview
The Contribution of the Urokinase Plasminogen Activator and the Urokinase Receptor to Pleural and Parenchymal Lung Injury and Repair: A Narrative Review
Int. J. Mol. Sci. 2021, 22(3), 1437; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031437 - 01 Feb 2021
Abstract
Pleural and parenchymal lung injury have long been characterized by acute inflammation and pathologic tissue reorganization, when severe. Although transitional matrix deposition is a normal part of the injury response, unresolved fibrin deposition can lead to pleural loculation and scarification of affected areas. [...] Read more.
Pleural and parenchymal lung injury have long been characterized by acute inflammation and pathologic tissue reorganization, when severe. Although transitional matrix deposition is a normal part of the injury response, unresolved fibrin deposition can lead to pleural loculation and scarification of affected areas. Within this review, we present a brief discussion of the fibrinolytic pathway, its components, and their contribution to injury progression. We review how local derangements of fibrinolysis, resulting from increased coagulation and reduced plasminogen activator activity, promote extravascular fibrin deposition. Further, we describe how pleural mesothelial cells contribute to lung scarring via the acquisition of a profibrotic phenotype. We also discuss soluble uPAR, a recently identified biomarker of pleural injury, and its diagnostic value in the grading of pleural effusions. Finally, we provide an in-depth discussion on the clinical importance of single-chain urokinase plasminogen activator (uPA) for the treatment of loculated pleural collections. Full article
(This article belongs to the Special Issue The Role of Fibrinolytic System in Health and Disease)
Show Figures

Figure 1

Open AccessReview
The Central Role of Fibrinolytic Response in COVID-19—A Hematologist’s Perspective
Int. J. Mol. Sci. 2021, 22(3), 1283; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031283 - 28 Jan 2021
Abstract
The novel coronavirus disease (COVID-19) has many characteristics common to those in two other coronavirus acute respiratory diseases, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). They are all highly contagious and have severe pulmonary complications. Clinically, patients with COVID-19 [...] Read more.
The novel coronavirus disease (COVID-19) has many characteristics common to those in two other coronavirus acute respiratory diseases, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). They are all highly contagious and have severe pulmonary complications. Clinically, patients with COVID-19 run a rapidly progressive course of an acute respiratory tract infection with fever, sore throat, cough, headache and fatigue, complicated by severe pneumonia often leading to acute respiratory distress syndrome (ARDS). The infection also involves other organs throughout the body. In all three viral illnesses, the fibrinolytic system plays an active role in each phase of the pathogenesis. During transmission, the renin-aldosterone-angiotensin-system (RAAS) is involved with the spike protein of SARS-CoV-2, attaching to its natural receptor angiotensin-converting enzyme 2 (ACE 2) in host cells. Both tissue plasminogen activator (tPA) and plasminogen activator inhibitor 1 (PAI-1) are closely linked to the RAAS. In lesions in the lung, kidney and other organs, the two plasminogen activators urokinase-type plasminogen activator (uPA) and tissue plasminogen activator (tPA), along with their inhibitor, plasminogen activator 1 (PAI-1), are involved. The altered fibrinolytic balance enables the development of a hypercoagulable state. In this article, evidence for the central role of fibrinolysis is reviewed, and the possible drug targets at multiple sites in the fibrinolytic pathways are discussed. Full article
(This article belongs to the Special Issue The Role of Fibrinolytic System in Health and Disease)
Show Figures

Figure 1

Back to TopTop