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Special Issue "Trace Amine-Associated Receptors in Neuropsychiatric Disorders"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 May 2021.

Special Issue Editor

Dr. Grazia Rutigliano
E-Mail Website
Guest Editor
Department of Pathology, University of Pisa, Pisa, Italy
Interests: psychosis; bipolar disorder; at-risk mental states; thyroid hormone; thyronamine; trace amine-associated receptors; endocrine disruptors

Special Issue Information

Dear Colleagues,

In the two decades since its discovery, pre-clinical evidence has been accumulating about the role of trace amine-associated receptor 1 (TAAR1) in the central nervous system. TAAR1 is a G protein-coupled receptor, widely expressed across the mammalian brain, mainly in limbic and monoaminergic areas involved in the regulation of emotion, cognition and reward. TAAR1 has a tonic inhibitory control on dopaminergic and serotonergic neurotransmission and influences the composition and function of NMDA glutamatergic receptors. TAAR1 knock out (KO) mice are characterized by impairment in sensorimotor gating functions, perseverative and impulsive behaviors, and worse learning performances, which represent phenotypes relevant to neurodevelopmental disorders and schizophrenia. Furthermore, TAAR1-KO mice present an enhanced sensitivity to the addictive effects of amphetamine, methamphetamine, MDMA, and ethanol. These experimental observations prompted the development of TAAR1 agonists to be exploited for the treatment of neuropsychiatric disorders. This Special Issue is dedicated to the recent evidence about the pathophysiological role of TAAR1 in the central nervous system and the exploitation of this recently discovered signaling system as a target for the treatment of neuropsychiatric disorders, also in the presence of co-morbid addictive disorders and metabolic disturbances.

Dr. Grazia Rutigliano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • TAAR1
  • schizophrenia
  • addiction
  • dopamine
  • glutamate
  • neurocognition

Published Papers

This special issue is now open for submission.
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