Special Issue "A Disintegrin and Metalloproteases (ADAMs): Activation, Regulation and Mechanisms of Catalysis"
Deadline for manuscript submissions: 15 March 2021.
ADAMs is a family of multidomain cell surface proteases that contain a disintegrin and a metalloprotease domains. While these proteins were initially identified as sperm-specific proteins with similarities to snake venom metalloproteases and shown to play important roles in fertilization processes, they have now been demonstrated to be critical for diverse cellular functions including cell growth, signaling, hematopoiesis, and immune and inflammatory responses. Specifically, two ADAMs, ADAM10 and ADAM17, are indispensable for normal development as ADAM10 controls Notch function and ADAM17 regulates epidermal growth factor receptor and tumor necrosis factor signaling. The regulation and activation of these two ADAMs is rapid and mostly occurs post-translationally in response to many different stimuli, such as endotoxins, ion influx, and lipid modifiers. Most other ADAMs appear to have constitutive catalytic activity that is regulated by their expression levels rather than an on/off switch. Many of these are not essential for normal development, but their dysregulation has been implicated in the development of cancer and other diseases.
The aim of this Special Issue of IJMS is to provide novel insights into the physiological and pathological functions of these membrane-anchored molecular scissors. To this end, we welcome experts in the field to contribute research articles and critical reviews on molecular mechanisms involved in the regulation of these fascinating enzymes, such as how they target their substrates, how they are activated, and their functions in development and disease, with special attention paid to their potential as therapeutic targets in areas such as inflammatory and metabolic disorders, cancer, and autoimmune diseases.
Dr. Thorsten Maretzky
Manuscript Submission Information
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- ectodomain shedding
- catalytic mechanisms
- therapeutic targeting