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Special Issue "Adipocyte Functionality in Whole-Body Metabolic Regulation"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Dr. Ingrid Wernstedt Asterholm
E-Mail Website
Guest Editor
Department of Physiology, Molecular Physiology Research Unit, Sahlgrenska Academy, Institute of Neuroscience and Physiology, Gothenburg University, Box 432, SE-40530 Gothenburg, Sweden
Interests: adipose tissue biology; metabolism; adipose tissue remodeling; adipocyte; macrophage; mitochondria

Special Issue Information

Dear Colleagues,

Adipose tissue functionality plays a key role in the regulation of whole-body metabolism. Functional adipose tissue can effectively expand to store excess nutrients during caloric overload – that way, other tissues are protected against deleterious lipid deposition. Besides this energy storage function, adipose tissue secretes a large number of cytokines and hormones (commonly referred to as adipokines) that affect immunological and metabolic processes locally as well as systemically.

However, these adipose tissue functions are often impaired in obesity. While healthy adipose tissue displays appropriate interplay between different adipose tissue-resident cells such as adipocytes and macrophages, obese dysfunctional adipose tissue is characterized by overactive innate and adaptive immune responses in addition to disturbed adipokine release. Moreover, dysfunctional adipose tissue may also display altered mitochondrial function as well as enhanced adipocyte hypertrophy, implying reduced recruitment of new adipocytes.

In this Special Issue of IJMS, the focus will be on expanding adipose tissue and the resulting issues that trigger loss of proper immune regulation and adipocyte dysfunction.

Dr. Ingrid Wernstedt Asterholm
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • adipose tissue
  • innate immunity
  • adaptive immunity
  • tissue remodeling
  • adipokines
  • obesity

Published Papers

This special issue is now open for submission.
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