Special Issue "Adipocyte Functionality in Whole-Body Metabolic Regulation"
Deadline for manuscript submissions: 31 October 2021.
Interests: adipose tissue biology; metabolism; adipose tissue remodeling; adipocyte; macrophage; mitochondria
Adipose tissue functionality plays a key role in the regulation of whole-body metabolism. Functional adipose tissue can effectively expand to store excess nutrients during caloric overload – that way, other tissues are protected against deleterious lipid deposition. Besides this energy storage function, adipose tissue secretes a large number of cytokines and hormones (commonly referred to as adipokines) that affect immunological and metabolic processes locally as well as systemically.
However, these adipose tissue functions are often impaired in obesity. While healthy adipose tissue displays appropriate interplay between different adipose tissue-resident cells such as adipocytes and macrophages, obese dysfunctional adipose tissue is characterized by overactive innate and adaptive immune responses in addition to disturbed adipokine release. Moreover, dysfunctional adipose tissue may also display altered mitochondrial function as well as enhanced adipocyte hypertrophy, implying reduced recruitment of new adipocytes.
In this Special Issue of IJMS, the focus will be on expanding adipose tissue and the resulting issues that trigger loss of proper immune regulation and adipocyte dysfunction.
Dr. Ingrid Wernstedt Asterholm
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- adipose tissue
- innate immunity
- adaptive immunity
- tissue remodeling