ijms-logo

Journal Browser

Journal Browser

Special Issue "Alcohol-Induced Liver Injury 2021"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editor

Prof. Dr. Akiko Kojima-Yuasa
E-Mail
Guest Editor
Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, Osaka, Japan
Interests: alcoholic liver disease; functional foods; reactive oxygen species; antioxidant activity; hepatocytes; hepatic stellate cells; lifestyle-related disease; anti-obesity; anti-cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic alcohol abuse is a significant cause of cirrhosis and liver failure in adults worldwide. Alcoholic liver disease (ALD) is a pathological process characterized by progressive liver damage that leads to steatosis, steatohepatitis, fibrosis, and finally cirrhosis. Eventually, cirrhosis may progress to hepatic decompensation and hepatocellular cancer. Therefore, ALD is an important cause of morbidity and mortality. There is an urgent need to develop efficient strategies for patients with ALD.

Although remarkable achievements has been made in the mechanisms of ALD, there is still no effective therapy for ALD. Recently, there has been growing studies in elucidating the role of foods and food components as suppressors of alcohol–induced oxidative stress and liver damage.

This Special Issue would like to deepen the relationship between food components and preventive effect for ALD. The studies using in vitro and/or in vivo models are welcome.

Prof. Dr. Akiko Kojima-Yuasa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Alcoholic liver disease
  • Hepatitis
  • Liver fibrosis
  • Food components
  • Hepatocyte
  • Hepatic stellate cells
  • Reactive oxygen species
  • Alcohol dehydrogenase
  • Cytochrome P450 2E1

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

Review
Pathophysiological Aspects of Alcohol Metabolism in the Liver
Int. J. Mol. Sci. 2021, 22(11), 5717; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22115717 - 27 May 2021
Cited by 1 | Viewed by 809
Abstract
Alcoholic liver disease (ALD) is a globally prevalent chronic liver disease caused by chronic or binge consumption of alcohol. The liver is the major organ that metabolizes alcohol; therefore, it is particularly sensitive to alcohol intake. Metabolites and byproducts generated during alcohol metabolism [...] Read more.
Alcoholic liver disease (ALD) is a globally prevalent chronic liver disease caused by chronic or binge consumption of alcohol. The liver is the major organ that metabolizes alcohol; therefore, it is particularly sensitive to alcohol intake. Metabolites and byproducts generated during alcohol metabolism cause liver damage, leading to ALD via several mechanisms, such as impairing lipid metabolism, intensifying inflammatory reactions, and inducing fibrosis. Despite the severity of ALD, the development of novel treatments has been hampered by the lack of animal models that fully mimic human ALD. To overcome the current limitations of ALD studies and therapy development, it is necessary to understand the molecular mechanisms underlying alcohol-induced liver injury. Hence, to provide insights into the progression of ALD, this review examines previous studies conducted on alcohol metabolism in the liver. There is a particular focus on the occurrence of ALD caused by hepatotoxicity originating from alcohol metabolism. Full article
(This article belongs to the Special Issue Alcohol-Induced Liver Injury 2021)
Show Figures

Figure 1

Back to TopTop