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Special Issue "Amino Acid Metabolism and Regulation in Health and Disease 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Prof. Dr. Madhav Bhatia
E-Mail Website
Guest Editor
Department of Pathology and Biomedical Science, University of Otago, Christchurch, 2 Riccarton Avenue, PO Box 4345, Christchurch 8140, New Zealand
Interests: inflammation; acute pancreatitis; sepsis; burn injury; arthritis; hydrogen sulfide; substance P; chemokines; leukocytes
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Prof. Dr. Isao Ishii
E-Mail Website1 Website2
Guest Editor
Laboratory of Health Chemistry, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan
Interests: amino acid metabolism; homocysteine; hydrogen sulfide; lysophospholipid signaling; proteomics; metabolomics; signal transduction
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Amino acids, the primary component of proteins, are not stored in the human body, unlike carbohydrates and fats. The (free) amino acid pool is estimated to be only ~100 g in comparison with the amount of proteins (~12 kg) in a 70 kg person. Therefore, amino acids must be obtained from the diet, synthesized de novo (as are the eleven non-essential amino acids), or supplied from endogenous protein degradation. Amino acids can then be used for protein synthesis, the conversion to various nitrogen-containing essential biomolecules including neurotransmitters, purines and pyrimidines, porphyrins, creatine, and gaseous transmitters (NO, CO, and H2S), as well as an energy source. Six decades have passed since the identification of inborn errors in amino acid metabolism such as phenylketonuria, maple syrup disease, and homocystinuria. Thereafter, a growing body of evidence is accumulating to show the involvement of dysregulated amino acid metabolism in various aspects of common acquired disease conditions such as cardiovascular diseases, oncogenesis/tumor progression/metastasis, inflammation/autoimmune diseases, and metabolic syndrome. The Special Issue, “Amino Acid Metabolism and Regulation in Health and Disease”, of the International Journal of Molecular Sciences will include a selection of original research papers and reviews on the molecular and cellular biology of amino acids, including recently discovered fundamental aspects of regulation by bioactive amino acids (mTOR signaling and autophagy, sensing of amino acids by aminoacyl-tRNA synthetases), their metabolites (NO, H2S, homocysteine, and glutathione), and post-translational protein modification (S-nitrosylation, S-sulfhydration, S-glutathionylation, S- and N-homocysteinylation, and lysine residue aminoacylation), and their roles in health and disease.

Prof. Dr. Madhav Bhatia
Prof. Dr. Isao Ishii
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • amino acids
  • amino acid derivatives
  • metabolism
  • aminoacyl-tRNA synthetases
  • protein modification
  • autophagy
  • mTOR signaling

Published Papers

This special issue is now open for submission.
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