Special Issue "Animal Models of Melanoma"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 December 2017).
2. Pathology and Laboratory Medicine Service, VA Medical Center, Birmingham, AL 35294, USA
Interests: dermatopathology; skin pigmentation; neuroendocrinology of the skin; photobiology; melanoma; steroidogenesis; vitamin D; sterols; melatonin; stress response mechanisms
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Interests: melanoma; cancer genetics; epigenetics; metabolism; cancer immunology
Interests: UV-induced melanoma; metastasis; metastasis suppressor genes; melanoma biomarkers; growth factors; transcriptional regulation; DNA repair; stem cell biology
Malignant melanoma represents a significant problem in the human population, exhibiting the highest mortality rate of all skin cancers as well as a high incidence across different age groups. When the disease is localized to the skin (in situ, or is at the radial growth phase), cures are usually achieved by surgical excision. However, melanomas gain metastatic potential upon entering the vertical growth phase, indicating the importance of early and accurate histopathological diagnosis. Melanomas localized to the skin at stage II and metastatic melanomas (stages III and IV) represent particularly difficult challenges for therapy. Despite impressive recent progress in development of new therapies for metastatic disease (targeted therapy, immunotherapy, etc.), prospects for long-term survival remain grim for most patients due to acquired resistance to these agents. Moreover, these therapies are limited by adverse side effects and their high costs. Clearly the need is great for development of new strategies for advanced melanoma with long-term efficacy, improved toxicity profiles and lower costs. In this regard, a key element for progress is the utilization of appropriate animal models. Several models for human melanoma have been developed in rodents and other animals that recapitulate advanced, metastatic forms of the disease and can be employed for these efforts. This issue reviews the current state-of-the-art for experimental animal models of human melanoma, and outlines potential approaches for their application to the development of novel strategies for effective management and cure of this devastating disease.
Prof. Dr. Andrzej Slominski
Prof. Dr. Marcus W. Bosenberg
Prof. Dr. David M. Kaetzel
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- Rodent models
- Genetically engineered mouse models (GEMMs)
- Metastasis suppressor and driver genes
- Melanoma patient derived xenografts (PDXs)