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Special Issue "Antioxidant Therapies in Acute and Chronic Neurodegenerations"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 January 2022.

Special Issue Editors

Prof. Dr. Giuseppe Lazzarino
E-Mail Website
Guest Editor
Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, 95123 Catania, Italy
Interests: mitochondrial dysfunction; energy metabolism; oxidative/nitrosative stress; antioxidants; neurodegenerations; traumatic brain injury; concussion and sports-related concussion; male and female infertility; HPLC analysis of metabolites
Special Issues and Collections in MDPI journals
Prof. Dr. Barbara Tavazzi
E-Mail Website
Guest Editor
Department of Basic Biotechnological Sciences, Intensive and Perioperative Clinics – Biochemistry Section, Catholic University of Rome, and Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, Rome, Italy
Interests: neurodegenerative acute (traumatic brain injury) and chronic (multiple sclerosis) disorders; oxidative and nitrosative stresses; oxidation mechanisms; antioxidants; metabolomics; biochemical analytical techniques; lipid peroxidation products; dietary antioxidants; carotenoids; polyphenols; vitamin E; vitamin C; antioxidant activity/capacity
Special Issues and Collections in MDPI journals
Prof. Dr. Giacomo Lazzarino
E-Mail Website
Guest Editor
UNICAMILLUS International University of Health and Medical Sciences, Via di Sant'Alessandro, 8 00131, Rome, Italy
Interests: mitochondrial dysfunction; oxidative/nitrosative stress; neurodegenerations; multiple sclerosis; traumatic brain injury; metabolic cell reprogramming
Dr. Giuseppe Caruso
E-Mail Website
Guest Editor
Department of Drug and Health Sciences, University of Catania, 95125 Catania, Italy
Interests: carnosine; microglia/macrophages; inflammation; oxidative stress; Alzheimer’s disease; transforming growth factor-beta 1 (TGF-β1); neurodegeneration
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Acute (cerebral ischemia, traumatic brain injury) and chronic neurodegenerations (Alzheimer’s disease, Parkinson disease, amyotrophic lateral sclerosis, multiple sclerosis, Huntington disease), although caused by substantially different mechanisms, have some molecular features in common, including sustained oxidative/nitrosative stress, decreased antioxidant defenses, mitochondrial dysfunction with energy penalty, and neuroinflammation. Molecular and clinical damages in acute neurodegenerations are not necessarily progressive, although repeated episodes of acute neurodegenerations, of even mild severity, may evolve into chronic neurodegenerations, as occurs in repeated sports-related concussions potentially evolving into chronic traumatic encephalopathy (CTE). Differently, damages caused by chronic neurodegenerations progress at molecular level and are mirrored by worsening of patient clinical conditions (loss of cognitive and/or psychomotor functions). In the last decade, great attention has been given to the possibility of reducing the damaging effects produced by sustained oxidative/nitrosative stress as a key (and common) phenomenon involved in the molecular damages caused by acute and chronic neurodegenerations. Therefore, testing the effects of antioxidant administration to limit the damages of acute head injuries and to counteract progression of chronic neurodegenerations appears to be a therapeutic approach of great potential clinical utility.

This Special Issue is dedicated to preclinical and clinical studies significantly updating our knowledge on antioxidant therapies in acute and chronic neurodegenerations. Original articles should not simply be a phenomenological presentation of the data but should contain mechanistic indications on the eventual benefits produced by the antioxidant(s) in the selected pathology. Review articles are also welcome but they should contain an evaluation of the molecular aspects of the antioxidant-based therapies to date tested.

Prof. Dr. Giuseppe Lazzarino
Prof. Dr. Barbara Tavazzi
Prof. Dr. Giacomo Lazzarino
Dr. Giuseppe Caruso
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute and chronic neurodegenerations
  • oxidative/nitrosative stress
  • antioxidants
  • mitochondrial dysfunction
  • neuroinflammation

Published Papers

This special issue is now open for submission.
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