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Antitumor Properties of Nanoparticles
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Antitumor Properties of Nanoparticles

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biophysics".

Deadline for manuscript submissions: closed (28 January 2022) | Viewed by 7171

Special Issue Editor

Dr. Mateusz Wierzbicki

E-Mail Website
Guest Editor
Department of Nanobiotechnology, Institute of Biology, Warsaw University of Life Sciences, 02-787 Warsaw, Poland
Interests: nanoparticles; carbon nanoparticles; tumor biology; tumor microenvironment; angiogenesis; wound healing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Despite developments in medicine and diagnostic fields, tumors remain among the leading causes of death throughout the world. Nanoparticles have been explored for biomedical applications, and are considered as a possible choice for experimental tumor therapies and drug delivery strategies. The unique properties of nanoparticles and the possibility of chemical modification and attachment of active substances allow the materials to be well-adapted to targeted antitumor therapies. Despite the great interest, the use of nanoparticles in antitumor therapies requires further research, particularly regarding the understanding of their biological interactions and distribution in the body and individual tissues.

Therefore, authors are invited to submit original research and review articles on the antitumor properties of nanoparticles and nanoparticles conjugates. Topics include, but are not limited to:

  • Toxicity;
  • Interactions with cell cycle and biological pathways;
  • Regulation of key tumor physiology processes including migration, invasiveness, autophagy, and angiogenesis;
  • Interaction with the tumor microenvironment;
  • Distribution in tissues and model organisms.

Dr. Mateusz Wierzbicki
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • nanoparticle conjugates
  • nanoparticles toxicity
  • tumor development
  • biological pathways
  • angiogenesis
  • migration
  • invasiveness
  • autophagy
  • angiogenesis
  • tumor microenvironment

Published Papers (3 papers)

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Research

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13 pages, 3752 KiB  
Article
Biological Evaluation of Photodynamic Effect Mediated by Nanoparticles with Embedded Porphyrin Photosensitizer
by Ludmila Žárská, Zuzana Malá, Kateřina Langová, Lukáš Malina, Svatopluk Binder, Robert Bajgar, Petr Henke, Jiří Mosinger and Hana Kolářová
Int. J. Mol. Sci. 2022, 23(7), 3588; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23073588 - 25 Mar 2022
Cited by 3 | Viewed by 1692
Abstract
Clinically approved photodynamic therapy (PDT) is a minimally invasive treatment procedure that uses three key components: photosensitization, a light source, and tissue oxygen. However, the photodynamic effect is limited by both the photophysical properties of photosensitizers as well as their low selectivity, leading [...] Read more.
Clinically approved photodynamic therapy (PDT) is a minimally invasive treatment procedure that uses three key components: photosensitization, a light source, and tissue oxygen. However, the photodynamic effect is limited by both the photophysical properties of photosensitizers as well as their low selectivity, leading to damage to adjacent normal tissue and/or inadequate biodistribution. Nanoparticles (NPs) represent a new option for PDT that can overcome most of the limitations of conventional photosensitizers and can also promote photosensitizer accumulation in target cells through enhanced permeation and retention effects. In this in vitro study, the photodynamic effect of TPP photosensitizers embedded in polystyrene nanoparticles was observed on the non-tumor NIH3T3 cell line and HeLa and G361 tumor cell lines. The efficacy was evaluated by viability assay, while reactive oxygen species production, changes in membrane mitochondrial potential, and morphological changes before and after treatment were imaged by atomic force microscopy. The tested nanoparticles with embedded TPP were found to become cytotoxic only after activation by blue light (414 nm) due to the production of reactive oxygen species. The photodynamic effect observed in this evaluation was significantly higher in both tumor lines than the effect observed in the non-tumor line, and the resulting phototoxicity depended on the concentration of photosensitizer and irradiation time. Full article
(This article belongs to the Special Issue Antitumor Properties of Nanoparticles)
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21 pages, 7524 KiB  
Article
Effects of Metallic and Carbon-Based Nanomaterials on Human Pancreatic Cancer Cell Lines AsPC-1 and BxPC-3
by Barbara Wójcik, Ewa Sawosz, Jarosław Szczepaniak, Barbara Strojny, Malwina Sosnowska, Karolina Daniluk, Marlena Zielińska-Górska, Jaśmina Bałaban, André Chwalibog and Mateusz Wierzbicki
Int. J. Mol. Sci. 2021, 22(22), 12100; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222212100 - 09 Nov 2021
Cited by 7 | Viewed by 2637
Abstract
Pancreatic cancer, due to its asymptomatic development and drug-resistance, is difficult to cure. As many metallic and carbon-based nanomaterials have shown anticancer properties, we decided to investigate their potential use as anticancer agents against human pancreatic adenocarcinoma. The objective of the study was [...] Read more.
Pancreatic cancer, due to its asymptomatic development and drug-resistance, is difficult to cure. As many metallic and carbon-based nanomaterials have shown anticancer properties, we decided to investigate their potential use as anticancer agents against human pancreatic adenocarcinoma. The objective of the study was to evaluate the toxic properties of the following nanomaterials: silver (Ag), gold (Au), platinum (Pt), graphene oxide (GO), diamond (ND), and fullerenol (C60(OH)40) against the cell lines BxPC-3, AsPC-1, HFFF-2, and HS-5. The potential cytotoxic properties were evaluated by the assessment of the cell morphology, cell viability, and cell membrane damage. The cancer cell responses to GO and ND were analysed by determination of changes in the levels of 40 different pro-inflammatory proteins. Our studies revealed that the highest cytotoxicity was obtained after the ND treatment. Moreover, BxPC-3 cells were more sensitive to ND than AsPC-1 cells due to the ND-induced ROS production. Furthermore, in both of the cancer cell lines, ND caused an increased level of IL-8 and a decreased level of TIMP-2, whereas GO caused only decreased levels of TIMP-2 and ICAM-1 proteins. This work provides important data on the toxicity of various nanoparticles against pancreatic adenocarcinoma cell lines. Full article
(This article belongs to the Special Issue Antitumor Properties of Nanoparticles)
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Review

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13 pages, 3415 KiB  
Review
Engineering Nanoplatform for Combined Cancer Therapeutics via Complementary Autophagy Inhibition
by Xuan Wang, Yunhao Li, Jianqing Lu, Xiongwei Deng and Yan Wu
Int. J. Mol. Sci. 2022, 23(2), 657; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23020657 - 07 Jan 2022
Cited by 2 | Viewed by 2207
Abstract
Despite advances in the development of tumor treatments, mortality from cancer continues to increase. Nanotechnology is expected to provide an innovative anti-cancer therapy, to combat challenges such as multidrug resistance and tumor recurrence. Nevertheless, tumors can greatly rely on autophagy as an alternative [...] Read more.
Despite advances in the development of tumor treatments, mortality from cancer continues to increase. Nanotechnology is expected to provide an innovative anti-cancer therapy, to combat challenges such as multidrug resistance and tumor recurrence. Nevertheless, tumors can greatly rely on autophagy as an alternative source for metabolites, and which desensitizes cancer cells to therapeutic stress, hindering the success of any current treatment paradigm. Autophagy is a conserved process by which cells turn over their own constituents to maintain cellular homeostasis. The multistep autophagic pathway provides potentially druggable targets to inhibit pro-survival autophagy under various therapeutic stimuli. In this review, we focus on autophagy inhibition based on functional nanoplatforms, which may be a potential strategy to increase therapeutic sensitivity in combinational cancer therapies, including chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, and immunotherapy. Full article
(This article belongs to the Special Issue Antitumor Properties of Nanoparticles)
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