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Special Issue "Astrocytes: Emerging Roles in the Pathogenesis and Treatment of CNS Disorders 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editors

Prof. Dr. Yukihiro Ohno
E-Mail Website
Guest Editor
Department of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan
Interests: astrocytes; neuron–glia interaction; synaptic release; monoamine neurons; Parkinson’s disease; epilepsy; schizophrenia; mood disorders
Special Issues and Collections in MDPI journals
Prof. Dr. Schuichi Koizumi
E-Mail Website
Guest Editor
Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan
Interests: astrocytes; microglia; neuron–glia interaction; P2 receptors; ischemia; synaptogenesis
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Astrocytes are the major glial cells and play crucial roles in maintaining the structural and functional integrity of the brain, participating in the formation of the blood–brain barrier, the maintenance of water and ion homeostasis, the metabolism of neurotransmitters, and the secretion of various neuroactive molecules (e.g., gliotransmitters, neurotrophic factors, and cytokines). Moreover, a new vision emerges from the recent progress in astrocyte research that astrocytes serve as a promising target in the treatment of various central nervous system (CNS) disorders, such as schizophrenia, major depression, pain, epilepsy, ischemic stroke, Parkinson’s disease, Alzheimer’s disease, and other neurodegenerative disorders (e.g., amyotrophic lateral sclerosis and multiple sclerosis). The primary purpose of this Special Issue is to collect scientific contributions providing novel insights into the roles of astrocytes in modulating CNS disorders.

Prof. Dr. Yukihiro Ohno
Prof. Dr. Schuichi Koizumi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Astrocytes
  • Neuron–Glia interactions
  • Gliotransmitters
  • Neurotrophic factors
  • Neurodegenerative disorders
  • Psychiatric disorders
  • Epilepsy
  • Pain

Published Papers (1 paper)

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Research

Open AccessArticle
Mapping Astrocyte Transcriptional Signatures in Response to Neuroactive Compounds
Int. J. Mol. Sci. 2021, 22(8), 3975; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22083975 - 12 Apr 2021
Viewed by 381
Abstract
Astrocytes play central roles in normal brain function and are critical components of synaptic networks that oversee behavioral outputs. Despite their close affiliation with neurons, how neuronal-derived signals influence astrocyte function at the gene expression level remains poorly characterized, largely due to difficulties [...] Read more.
Astrocytes play central roles in normal brain function and are critical components of synaptic networks that oversee behavioral outputs. Despite their close affiliation with neurons, how neuronal-derived signals influence astrocyte function at the gene expression level remains poorly characterized, largely due to difficulties associated with dissecting neuron- versus astrocyte-specific effects. Here, we use an in vitro system of stem cell-derived astrocytes to identify gene expression profiles in astrocytes that are influenced by neurons and regulate astrocyte development. Furthermore, we show that neurotransmitters and neuromodulators induce distinct transcriptomic and chromatin accessibility changes in astrocytes that are unique to each of these neuroactive compounds. These findings are highlighted by the observation that noradrenaline has a more profound effect on transcriptional profiles of astrocytes compared to glutamate, gamma-aminobutyric acid (GABA), acetylcholine, and serotonin. This is demonstrated through enhanced noradrenaline-induced transcriptomic and chromatin accessibility changes in vitro and through enhanced calcium signaling in vivo. Taken together, our study reveals distinct transcriptomic and chromatin architecture signatures in astrocytes in response to neuronal-derived neuroactive compounds. Since astrocyte function is affected in all neurological disorders, this study provides a new entry point for exploring genetic mechanisms of astrocyte–neuron communication that may be dysregulated in disease. Full article
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