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Special Issue "Research Progress in RNA-Binding Proteins"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 July 2021.

Special Issue Editor

Dr. Alexandre Smirnov
E-Mail Website
Guest Editor
UMR7156 - GMGM, University of Strasbourg, Strasbourg, France
CNRS, Strasbourg, FranceUniversity of Strasbourg Institute for Advanced Study, Strasbourg, France
Interests: RNA-binding proteins; noncoding RNA; ribonucleoproteins; interactomics; ribosome biogenesis; bacteria; mitochondria

Special Issue Information

Dear Colleagues,

RNA-binding proteins (RBPs) are omnipresent in biology. Makers, breakers, modifiers, and sensors of RNAs, they unavoidably shift into the research focus in fields as different as molecular and cell biology, molecular genetics, infection and immunity, synthetic biology and molecular medicine. They are also fascinating molecular objects with a stunning diversity of structures, RNA recognition modes, and activities. Stand-alone players or members of exuberant ribonucleoproteins, RBPs secure key housekeeping functions while also featuring in a number of accessory and regulatory roles. The last decade has seen a flurry of studies unravelling the genuine scope of RBP-mediated processes and molecular mechanisms. This Special Issue focuses on emerging molecular aspects of RBP biology and the new methods to approach them. This includes, but is not limited to, the recent progress in the prediction, identification, structural characterisation, and measurement of RNA-protein interactions, the biochemical behaviour and activities of RBPs, novel and classical RBP classes, phase-separation and formation of biocondensates, RBP evolution and design.

Dr. Alexandre Smirnov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • RNA-binding protein
  • RNA-protein interaction
  • ribonucleoprotein
  • RNA-protein complex
  • recognition
  • RNA metabolism
  • condensate
  • molecular evolution
  • protein design

Published Papers (1 paper)

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Research

Open AccessArticle
ATP-Independent Initiation during Cap-Independent Translation of m6A-Modified mRNA
Int. J. Mol. Sci. 2021, 22(7), 3662; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22073662 - 01 Apr 2021
Viewed by 282
Abstract
The methylation of adenosine in the N6 position (m6A) is a widely used modification of eukaryotic mRNAs. Its importance for the regulation of mRNA translation was put forward recently, essentially due to the ability of methylated mRNA to be translated [...] Read more.
The methylation of adenosine in the N6 position (m6A) is a widely used modification of eukaryotic mRNAs. Its importance for the regulation of mRNA translation was put forward recently, essentially due to the ability of methylated mRNA to be translated in conditions of inhibited cap-dependent translation initiation, e.g., under stress. However, the peculiarities of translation initiation on m6A-modified mRNAs are not fully known. In this study, we used toeprinting and translation in a cell-free system to confirm that m6A-modified mRNAs can be translated in conditions of suppressed cap-dependent translation. We show for the first time that m6A-modified mRNAs display not only decreased elongation, but also a lower efficiency of translation initiation. Additionally, we report relative resistance of m6A-mRNA translation initiation in the absence of ATP and inhibited eIF4A activity. Our novel findings indicate that the scanning of m6A-modified leader sequences is performed by a noncanonical mechanism. Full article
(This article belongs to the Special Issue Research Progress in RNA-Binding Proteins)
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