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Special Issue "Mechanisms in Biofilm Formation, Tolerance and Control"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 10 December 2021.

Special Issue Editors

Dr. Lúcia Chaves Simões
E-Mail Website
Guest Editor
CEB-Centre of Biological Engineering, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal
Interests: biofilm formation; biofilm control
Prof. Dr. Manuel Simões
E-Mail Website
Guest Editor
LEPABE, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Roberto Frias, s/n, 4200-465 Porto, Portugal
Interests: antimicrobial agents; emerging antimicrobial strategies; antimicrobial resistance; biofilms; plant secondary metabolites
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Research on biofilms has progressed rapidly in the last two decades. The scientific community has come to understand many things about the particular biology of microbial biofilms through a variety of microscopic, physical, chemical, and molecular techniques. Such advances provided fundamental insights for the management of biofilms by different approaches. For problematic biofilms, some studies seek to prevent biofilm formation, others aim to develop antimicrobial agents to treat existing biofilms, and others to disrupt the polymeric ties that bind the biofilms together. It is now clear that the study of biofilms requires a multidisciplinary approach, and that the knowledge on many of the aspects affecting biofilm formation and resistance remain superficial.

This Special Issue aims to collect the recent advances in biofilm research, particularly on the mechanisms underlying biofilm formation and tolerance to antimicrobials. Studies on control approaches targeting specific biofilm mechanisms are within the aim of this Special Issue.

Dr. Lúcia Chaves Simões
Prof. Dr. Manuel Simões
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • adhesion
  • antimicrobial action
  • antimicrobial resistance
  • biofilm development
  • biofilm matrix
  • biofilm structure
  • quorum sensing
  • motility
  • surfaces

Published Papers (1 paper)

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Biofilms in Diabetic Foot Ulcers: Impact, Risk Factors and Control Strategies
Int. J. Mol. Sci. 2021, 22(15), 8278; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22158278 - 31 Jul 2021
Cited by 1 | Viewed by 709
Diabetic foot ulcers (DFUs) are a serious complication from diabetes mellitus, with a huge economic, social and psychological impact on the patients’ life. One of the main reasons why DFUs are so difficult to heal is related to the presence of biofilms. [...] Read more.
Diabetic foot ulcers (DFUs) are a serious complication from diabetes mellitus, with a huge economic, social and psychological impact on the patients’ life. One of the main reasons why DFUs are so difficult to heal is related to the presence of biofilms. Biofilms promote wound inflammation and a remarkable lack of response to host defences/treatment options, which can lead to disease progression and chronicity. In fact, appropriate treatment for the elimination of these microbial communities can prevent the disease evolution and, in some cases, even avoid more serious outcomes, such as amputation or death. However, the detection of biofilm-associated DFUs is difficult due to the lack of methods for diagnostics in clinical settings. In this review, the current knowledge on the involvement of biofilms in DFUs is discussed, as well as how the surrounding environment influences biofilm formation and regulation, along with its clinical implications. A special focus is also given to biofilm-associated DFU diagnosis and therapeutic strategies. An overview on promising alternative therapeutics is provided and an algorithm considering biofilm detection and treatment is proposed. Full article
(This article belongs to the Special Issue Mechanisms in Biofilm Formation, Tolerance and Control)
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