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Optimization of Biomaterials for Reconstructive and Regenerative Medicine 2.0
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Optimization of Biomaterials for Reconstructive and Regenerative Medicine 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 18305

Special Issue Editors

Prof. Dr. Ralf Smeets

E-Mail Website
Guest Editor
Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
Interests: biomaterials; tissue engineering; resorbable metals; drug delivery systems; surface modifications
Special Issues, Collections and Topics in MDPI journals
Dr. Anders Henningsen

E-Mail Website
Guest Editor
Department of Oral and Maxillofacial Surgery, Division of Regenerative Orofacial Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
Interests: osseointegration; dental implants; biomaterials; non-thermal plasma; UV-light; platform switch implants; bone augmentation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The reconstruction and regeneration of body tissues is of great and ongoing clinical interest and relevance. Currently, many biomaterials have been introduced into the market, to be used for reconstructive or regenerative purposes.

Continuing research has made materials more biocompatible, resorbable, and less prone to foreign body reactions. The current aim of research on biomaterials is to promote and support a regeneration of the target tissue via complete biodegradation of the used biomaterials. In vitro, in vivo, and clinical studies are absolutely mandatory to evaluate cellular and molecular interactions with biomaterials as well as their behavior in living organisms.

In this Special Issue, we would like to outline current developments and trends regarding the optimization of biomaterials used for reconstructive and regenerative purposes. Thus, we welcome contributions (reviews and/or original papers) on new biomaterials, optimizations, surface modifications, innovative manufacturing or application methods and the behavior of these materials in vitro, in vivo or clinically.  

Prof. Dr. Ralf Smeets
Dr. Anders Henningsen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • biocompatible materials
  • tissue regeneration
  • reconstructive surgical procedures
  • tissue engineering
  • biomedical engineering
  • bioengineering
  • absorbable implants
  • dental implants

Related Special Issues

Published Papers (5 papers)

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Research

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17 pages, 4424 KiB  
Article
Impact of Fluid Dynamics on the Viability and Differentiation Capacity of 3D-Cultured Jaw Periosteal Cells
by Wanjing Cen, Suya Wang, Felix Umrath, Siegmar Reinert and Dorothea Alexander
Int. J. Mol. Sci. 2022, 23(9), 4682; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23094682 - 23 Apr 2022
Viewed by 1372
Abstract
Perfused bioreactor systems are considered to be a promising approach for the 3D culturing of stem cells by improving the quality of the tissue-engineered grafts in terms of better cell proliferation and deeper penetration of used scaffold materials. Our study aims to establish [...] Read more.
Perfused bioreactor systems are considered to be a promising approach for the 3D culturing of stem cells by improving the quality of the tissue-engineered grafts in terms of better cell proliferation and deeper penetration of used scaffold materials. Our study aims to establish an optimal perfusion culture system for jaw periosteal cell (JPC)-seeded scaffolds. For this purpose, we used beta-tricalcium phosphate (β-TCP) scaffolds as a three-dimensional structure for cell growth and osteogenic differentiation. Experimental set-ups of tangential and sigmoidal fluid configurations with medium flow rates of 100 and 200 µL/min were applied within the perfusion system. Cell metabolic activities of 3D-cultured JPCs under dynamic conditions with flow rates of 100 and 200 µL/min were increased in the tendency after 1, and 3 days of culture, and were significantly increased after 5 days. Significantly higher cell densities were detected under the four perfused conditions compared to the static condition at day 5. However, cell metabolic and proliferation activity under dynamic conditions showed flow rate independency in our study. In this study, dynamic conditions increased the expression of osteogenic markers (ALPL, COL1A1, RUNX2, and OCN) compared to static conditions and the tangential configuration showed a stronger osteogenic effect than the sigmoidal flow configuration. Full article
(This article belongs to the Special Issue Optimization of Biomaterials for Reconstructive and Regenerative Medicine 2.0)
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16 pages, 3152 KiB  
Article
Effect of Argon-Based Atmospheric Pressure Plasma Treatment on Hard Tissue Formation on Titanium Surface
by Satoshi Komasa, Tetsuji Kusumoto, Rina Hayashi, Seiji Takao, Min Li, Sifan Yan, Yuhao Zeng, Yuanyuan Yang, Hui Hu, Yasuyuki Kobayashi, Akinori Agariguchi, Hisataka Nishida, Yoshiya Hashimoto and Joji Okazaki
Int. J. Mol. Sci. 2021, 22(14), 7617; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147617 - 16 Jul 2021
Cited by 6 | Viewed by 2536
Abstract
In this paper, we suggest that the atmospheric pressure plasma treatment of pure titanium metal may be useful for improving the ability of rat bone marrow cells (RBMCs) to induce hard tissue differentiation. Previous studies have reported that the use of argon gas [...] Read more.
In this paper, we suggest that the atmospheric pressure plasma treatment of pure titanium metal may be useful for improving the ability of rat bone marrow cells (RBMCs) to induce hard tissue differentiation. Previous studies have reported that the use of argon gas induces a higher degree of hard tissue formation. Therefore, this study compares the effects of plasma treatment with argon gas on the initial adhesion ability and hard tissue differentiation-inducing ability of RBMCs. A commercially available titanium metal plate was used as the experimental material. A plate polished using water-resistant abrasive paper #1500 was used as the control, and a plate irradiated with argon mixed with atmospheric pressure plasma was used as the experimental plate. No structural change was observed on the surface of the titanium metal plate in the scanning electron microscopy results, and no change in the surface roughness was observed via scanning probe microscopy. X-ray photoelectron spectroscopy showed a decrease in the carbon peak and the formation of hydroxide in the experimental group. In the distilled water drop test, a significant decrease in the contact angle was observed for the experimental group, and the results indicated superhydrophilicity. Furthermore, the bovine serum albumin adsorption, initial adhesion of RBMCs, alkaline phosphatase activity, calcium deposition, and genetic marker expression of rat bone marrow cells were higher in the experimental group than those in the control group at all time points. Rat distal femur model are used as in vivo model. Additionally, microcomputed tomography analysis showed significantly higher results for the experimental group, indicating a large amount of the formed hard tissue. Histopathological evaluation also confirmed the presence of a prominent newly formed bone seen in the images of the experimental group. These results indicate that the atmospheric pressure plasma treatment with argon gas imparts superhydrophilicity, without changing the properties of the pure titanium plate surface. It was also clarified that it affects the initial adhesion of bone marrow cells and the induction of hard tissue differentiation. Full article
(This article belongs to the Special Issue Optimization of Biomaterials for Reconstructive and Regenerative Medicine 2.0)
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13 pages, 46036 KiB  
Article
Effect of Plasma Treatment on Titanium Surface on the Tissue Surrounding Implant Material
by Hitomi Tsujita, Hiroshi Nishizaki, Akiko Miyake, Seiji Takao and Satoshi Komasa
Int. J. Mol. Sci. 2021, 22(13), 6931; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22136931 - 28 Jun 2021
Cited by 9 | Viewed by 3201
Abstract
Early osseointegration is important to achieve initial stability after implant placement. We have previously reported that atmospheric-pressure plasma treatment confers superhydrophilicity to titanium. Herein, we examined the effects of titanium implant material, which was conferred superhydrophilicity by atmospheric-pressure plasma treatment, on the surrounding [...] Read more.
Early osseointegration is important to achieve initial stability after implant placement. We have previously reported that atmospheric-pressure plasma treatment confers superhydrophilicity to titanium. Herein, we examined the effects of titanium implant material, which was conferred superhydrophilicity by atmospheric-pressure plasma treatment, on the surrounding tissue in rat femur. Control and experimental groups included untreated screws and those irradiated with atmospheric-pressure plasma using piezobrush, respectively. The femurs of 8-week-old male Sprague-Dawley rats were used for in vivo experiments. Various data prepared from the Micro-CT analysis showed results showing that more new bone was formed in the test group than in the control group. Similar results were shown in histological analysis. Thus, titanium screw, treated with atmospheric-pressure plasma, could induce high hard tissue differentiation even at the in vivo level. This method may be useful to achieve initial stability after implant placement. Full article
(This article belongs to the Special Issue Optimization of Biomaterials for Reconstructive and Regenerative Medicine 2.0)
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15 pages, 35535 KiB  
Article
Silk Fiber-Reinforced Hyaluronic Acid-Based Hydrogel for Cartilage Tissue Engineering
by Jan-Tobias Weitkamp, Michael Wöltje, Bastian Nußpickel, Felix N. Schmidt, Dilbar Aibibu, Andreas Bayer, David Eglin, Angela R. Armiento, Philipp Arnold, Chokri Cherif, Ralph Lucius, Ralf Smeets, Bodo Kurz and Peter Behrendt
Int. J. Mol. Sci. 2021, 22(7), 3635; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22073635 - 31 Mar 2021
Cited by 13 | Viewed by 2958
Abstract
A continuing challenge in cartilage tissue engineering for cartilage regeneration is the creation of a suitable synthetic microenvironment for chondrocytes and tissue regeneration. The aim of this study was to develop a highly tunable hybrid scaffold based on a silk fibroin matrix (SM) [...] Read more.
A continuing challenge in cartilage tissue engineering for cartilage regeneration is the creation of a suitable synthetic microenvironment for chondrocytes and tissue regeneration. The aim of this study was to develop a highly tunable hybrid scaffold based on a silk fibroin matrix (SM) and a hyaluronic acid (HA) hydrogel. Human articular chondrocytes were embedded in a porous 3-dimensional SM, before infiltration with tyramine modified HA hydrogel. Scaffolds were cultured in chondropermissive medium with and without TGF-β1. Cell viability and cell distribution were assessed using CellTiter-Blue assay and Live/Dead staining. Chondrogenic marker expression was detected using qPCR. Biosynthesis of matrix compounds was analyzed by dimethylmethylene blue assay and immuno-histology. Differences in biomaterial stiffness and stress relaxation were characterized using a one-step unconfined compression test. Cell morphology was investigated by scanning electron microscopy. Hybrid scaffold revealed superior chondro-inductive and biomechanical properties compared to sole SM. The presence of HA and TGF-β1 increased chondrogenic marker gene expression and matrix deposition. Hybrid scaffolds offer cytocompatible and highly tunable properties as cell-carrier systems, as well as favorable biomechanical properties. Full article
(This article belongs to the Special Issue Optimization of Biomaterials for Reconstructive and Regenerative Medicine 2.0)
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Review

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34 pages, 6591 KiB  
Review
Bioengineering Clinically Relevant Cardiomyocytes and Cardiac Tissues from Pluripotent Stem Cells
by Emma Claire James, Eva Tomaskovic-Crook and Jeremy Micah Crook
Int. J. Mol. Sci. 2021, 22(6), 3005; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063005 - 16 Mar 2021
Cited by 8 | Viewed by 6970
Abstract
The regenerative capacity of cardiomyocytes is insufficient to functionally recover damaged tissue, and as such, ischaemic heart disease forms the largest proportion of cardiovascular associated deaths. Human-induced pluripotent stem cells (hiPSCs) have enormous potential for developing patient specific cardiomyocytes for modelling heart disease, [...] Read more.
The regenerative capacity of cardiomyocytes is insufficient to functionally recover damaged tissue, and as such, ischaemic heart disease forms the largest proportion of cardiovascular associated deaths. Human-induced pluripotent stem cells (hiPSCs) have enormous potential for developing patient specific cardiomyocytes for modelling heart disease, patient-based cardiac toxicity testing and potentially replacement therapy. However, traditional protocols for hiPSC-derived cardiomyocytes yield mixed populations of atrial, ventricular and nodal-like cells with immature cardiac properties. New insights gleaned from embryonic heart development have progressed the precise production of subtype-specific hiPSC-derived cardiomyocytes; however, their physiological immaturity severely limits their utility as model systems and their use for drug screening and cell therapy. The long-entrenched challenges in this field are being addressed by innovative bioengingeering technologies that incorporate biophysical, biochemical and more recently biomimetic electrical cues, with the latter having the potential to be used to both direct hiPSC differentiation and augment maturation and the function of derived cardiomyocytes and cardiac tissues by mimicking endogenous electric fields. Full article
(This article belongs to the Special Issue Optimization of Biomaterials for Reconstructive and Regenerative Medicine 2.0)
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