Special Issue "Biotransformation of Natural Products and Phytochemicals: Metabolites, Their Preparation and Properties"
Deadline for manuscript submissions: 30 September 2021.
Interests: polyphenols; flavonolignans; Silybum marianum; flavonols; quercetin; rutin; isoquercitrin; metabolites; gut microbiota; biotransformation by enzymes and whole cells
Special Issues and Collections in MDPI journals
Special Issue in Antioxidants: Biological Activity of Human Metabolites of Antioxidants
Interests: biocatalysis and biotransformation; immobilized microbial cells, their use in production and biotransformation of natural products; biotransformation of natural products by enzymes and microorganisms; preparation of glycosidases of microbial origin and their use for glycosylation of natural compounds: glycoconjugates, multivalent compounds, ergot alkaloids, flavonoids, antioxidants and chemoprotectants
Special Issues and Collections in MDPI journals
Special Issue in International Journal of Molecular Sciences: The Lignin Challenge: Exploring Innovative Applications
Special Issue in International Journal of Molecular Sciences: Molecular Transformations of Natural Products
Special Issue in International Journal of Molecular Sciences: Molecular Biocatalysis 2.0
Special Issue in International Journal of Molecular Sciences: Glycoconjugates and Glycomimetics for Targeting Lectins
Biotransformation features two major meanings: (i) biocatalysis and enzymatic modification of various compounds and (ii) biotransformation in terms of metabolic changes of xenobiotics in organism. In this special issue we want to focus on both connotations of biotransformation; specifically to the biotransformation of natural products and phytochemicals. Metabolites of xenobiotics have often different biological and biophysical properties compared to the parent compounds. Besides inactivation, also toxication and/or alteration of their activities often happen. Phytochemicals and other natural products have received increased attention due to their considerable benefits in preventing and managing chronic diseases. These compounds generally suffer from low bioavailability, they are extensively metabolized and their metabolites are often responsible for their biological effects. Therefore preparation and detailed study of their metabolites is of utmost importance. Due to the complexity of phytochemicals enzymatic methods were recently introduced in the preparation of their (tentative) metabolites. Topics for this Special Issue include the discovery of new chemical and biochemical methods for metabolite preparation including multienzyme methods, advanced structural and analytical methods for their characterization, and determination of biological and biophysical properties of the metabolites.
Major requirements for papers submitted to this Special Issue are (i) clear novelty; (ii) reproducibility; (iii) molecular bases of reactions and processes; and (iv) defined chemical reactions and structures. Papers dealing with minor optimizations of known procedures, those using poorly defined substrates and products and poorly defined biocatalysts (enzymes) or organisms unavailable to other researchers will be returned without further review.
Dr. Kateřina Valentová
Prof. Dr. Vladimír Křen
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- natural product biotransformation
- phytochemical metabolism
- preparation of metabolites
- cofactor regeneration
- multienzyme processes
- metabolite analysis and characterization
- toxicology of the metabolites