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Special Issue "cGMP-Signaling in Cells and Tissues: Molecular, Functional, and Pharmacological Aspects"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 March 2021.

Special Issue Editor

Special Issue Information

Dear Colleagues,

Cellular and tissue signaling by cGMP is an expanding field which comprises molecular function and (patho)physiology in various organ systems. cGMP synthesis, degradation, and function are modulated by a variety of signaling proteins and signal transduction pathways. Stuctural, biochemical, and (patho)physiological aspects have been strongly developed in the last decade, e.g., regarding cardiovascular, renal, pulmonary, gastrointestinal, and neuronal function. Dysregulation of cGMP generators (guanylyl cyclases), modulators (phosphodiesterases), and signaling molecules (e.g., kinases/substrates, channels) has been elucidated as the cause of pathophysiological processes and diseases. Pharmacological approaches have been propagated into pharmacological treatments including hypertension, cardiovascular, and gastrointestinal diseases. Therefore, the molecular and functional understanding of the diverse cGMP generators, signalling proteins, scaffolds, and signal transduction pathways is fundamental for insight into their (patho)physiological processes. The scope of the Special Issue is to summarize and enlarge the knowledge of these signaling processes and networks in diverse cells/tissues and to link it to (patho)physiological and pharmacological functions.

Therefore, authors are invited to submit original research and review articles which address the progress and current standing of cGMP signaling.

Topics include but are not limited to:

  • Identification of and new molecular and functional aspects in cGMP-signaling molecules and pathways;
  • Analysis of cGMP-signal generation, modulation, recognition, and/or its transduction into (patho)physiological responses and/or pharmacologcal approaches;
  • Techniques for the analysis and identification of cGMP signalling molecules, scaffolds, pathways, and networks.

Prof. Dr. Jens Schlossmann
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cGMP
  • signaling proteins
  • signal transduction pathways
  • scaffolds
  • nitric oxide
  • natriuretic peptides
  • guanylyl cyclases
  • kinases
  • phosphodiesterases
  • channels
  • (patho)physiology
  • pharmacology

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: In vivo function of the Inositol 1,4,5‑triphosphate receptor‑associated cGMP 

Author: Michael Majer, Jens Schloßmann

Summary: Kinase substrate 1 (IRAG1) in the context of anaemia and splenomegaly was investigated in 14‑weeks‑old global IRAG1‑deficient mice and wild type littermates. Therefore, we measured relevant blood parameters, spleen and body weight and examined faeces if there is any indication of gastrointestinal bleeding. To analyse which impact a loss of IRAG1 has on the NO/cGMP signalling pathway, the expression of mRNA and protein of several NO/cGMP signalling proteins (like the cGKIα and β) was investigated in colon, spleen and stomach. Taken together IRAG1‑deficient mice developed a splenomegaly‑associated anaemia and a change of expression NO/cGMP signalling proteins.

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