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Special Issue "Activations of Cadherin Signaling in Cancer 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 October 2021.

Special Issue Editor

Dr. Antonella Tomassetti
E-Mail Website
Guest Editor
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Unit of Molecular Therapies, Milan, Italy
Interests: signal transduction; cell adhesion; molecular markers; 3D tissue culture; epithelial ovarian cancer
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The members of the cadherin superfamily are cell–cell adhesion molecules, which are an important determinant of cellular interactions and tissue morphogenesis during development and are essential for the maintenance of adult tissue architecture.

In various types of cancer, cadherins and cadherin-associated or -related proteins are now thought to contribute at different levels to suppression, or initiation, or progression. Indeed, cadherins might act as signaling scaffolds for growth factor signalings, membrane trafficking networks, cytoskeletal remodeling, cell shape and polarity, and gene expression programs, thus positively or negatively contributing to proliferation and cell motility. For metastatic dissemination, the current model involves the process of the epithelial‐to‐mesenchymal transition (EMT), in which cancer cells undergo to the so-called ‘cadherin switch’, partially or completely losing their epithelial properties, detach and move as single cells, and form clonal metastases. Following novel and intriguing investigations, another theory is emerging of collective ‘epithelial metastases’, whereby groups of cancer cells invade and disseminate collectively to establish multiclonal metastases. Other regulatory mechanisms govern cadherin gene expression, trafficking, and processing, and these events integrate with other cellular signaling pathways to drive cancer cell behavior.

This Special Issue calls for original research, full reviews, and perspectives that address, in cancer cells, the current knowledge and the progress in understanding signaling involving cadherins, as well as efforts to develop inhibitors of pro-tumorigenic interactions. Contributions are not limited to the fields mentioned in the keywords.

Dr. Antonella Tomassetti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Cadherin
  • Catenin, actin cytoskeleton
  • EMT
  • Proliferation
  • Migration
  • Invasion
  • Metastasis
  • Gene expression
  • Protein degradation

Published Papers

This special issue is now open for submission.
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