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Special Issue "Mast Cells in Human Health and Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Prof. Dr. Giovanna Traina
E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences, Università degli Studi di Perugia, Perugia, Italy
Interests: Gene Expression; Inflammatory Bowel Disease; Cell Culture; Molecular Cell Biology; Neurophysiology
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues, 

Increasing evidence suggests that mast cells play a crucial role in human health and diseases.

Mast cells are known to be involved cells in allergic reactions through degranulation and the release of a variety of mediators with vasoactive, inflammatory, and nociceptive activities. Mast cells are sensors of the environment, able to respond promptly and selectively. Mast cells are intriguing and multifactorial cells and play a leading role in various pathological conditions.

The localization of mast cells within the tissue and their expression of specific mediators such as chymases or tryptases is important evidence from the diagnostic point of view. Chronic inflammation is a common mediator of various disorders which include many pathological conditions, pain, migraine, depression, anxiety, autoimmune diseases, fibromyalgia, but also Alzheimer’s disease, multiple sclerosis, atherosclerosis, and cardiovascular diseases. Modulation of the hyperactivity of mast cells and the reduction of the release of inflammatory factors could constitute a new frontier of therapeutic intervention aimed at preventing chronic inflammation.


  • New developments in mast cell management in human disorders
  • New molecular insights in mast cell control
  • Mast cells and microbiome
  • Mast cells and nociception
  • Mast cells and food allergy
  • Mast cells and neuroinflammation
  • Mast cells and stress

Prof. Dr. Giovanna Traina
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • mast cells
  • human diseases
  • pain
  • cardiovascular diseases
  • microbiome
  • food allergy
  • stress
  • cancer

Published Papers

This special issue is now open for submission.
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