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Special Issue "Multiomics Approaches in Biomedicine"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 March 2022.

Special Issue Editor

Prof. Dr. Sergei Moshkovskii
Guest Editor
1. Pirogov Russian National Research Medical University, 1, Ostrovityanova, 117997 Moscow, Russia
2. Federal Research and Clinical Center of Physical-Chemical Medicine, 1a, Malaya Pirogovskaya, 119435 Moscow, Russia
Interests: cancer proteomics; molecular biomarkers; proteogenomics; RNA editing; data processing in proteomics

Special Issue Information

Dear Colleagues,

The integration of high-throughput molecular data accompanies mass spectrometry-based proteomics from its very beginning. Up to now, the most efficient mode of proteome profiling was based on a search with the use of genomic sequence for the corresponding species. Since proteomics was able to quantify thousands of gene products, integration of transcriptome and proteome data became feasible, which provided new possibilities for system description and modelling of cellular processes. Furthermore, routine use of high-resolution mass spectrometry in proteomics made it possible to study the production of protein-coding genomic variants at the proteome level, which is especially important in cancer research, where mutations serve as drivers of malignant transformation. Integration of omics data for nucleic acids and proteins, called, sensu lato, proteogenomics, turned into a valuable instrument for biomedical research. Instruments and applications of proteogenomics are to be collected in the Special Issue.

Omics techniques that describe gene expression are currently taking the first steps towards single-cell resolution, and single-cell proteomics follows a fast growing transcriptomic approach. Thus, the cell proteogenomics is headlined with a perspective of single-cell data integration, which is not yet possible.

For this Special Issue, we invite authors to contribute original research articles, method papers, as well as review articles that will address recent developments in the area of proteogenomics in the broad sense of this term.

Potential topics include, but are not limited to, the following:

New methods of genomic, transcriptomic, and proteomic data integration;

multi-omics quantitative analysis of cellular mechanisms;

identification and functional analysis of genomic variants and mutations, particularly in cancer proteomes;

proteome recoding by post-transcriptional modifications, such as RNA editing;

genome reannotation using proteomic data;

proteomics for identification of neo-antigens;

identification and functional analysis of short open reading frames and their microproteins.

Prof. Dr. Sergei Moshkovskii
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • proteogenomics
  • multi-omics
  • proteome
  • mass-spectrometry
  • transcriptome
  • mutation
  • cancer genome
  • RNA editing
  • post-transcriptional modification

Published Papers

This special issue is now open for submission.
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