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Special Issue "Animal and Plant Cell–Tissue, Organ Specialization and Function: Investigational, Experimental and Medical Aspects 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editors

Prof. Dr. Bartosz Jan Płachno
E-Mail Website
Guest Editor
Department of Plant Cytology and Embryology, Institute of Botany, Faculty of Biology, Jagiellonian University in Kraków, 9 Gronostajowa St., 30-387 Cracow, Poland
Interests: plant cell ultrastructure; plant anatomy; nectaries and osmophores; plant pollination biology; carnivorous and parasitic plants
Special Issues and Collections in MDPI journals
Prof. Dr. Małgorzata Kotula-Balak
E-Mail Website
Guest Editor
University Center of Veterinary Medicine JU-UA, University of Agriculture in Krakow, Krakow, Poland
Interests: physiology; pathology; endocrine tissues; reproductive system; hormones; cell biology; receptor signaling
Special Issues and Collections in MDPI journals
Prof. Dr. Petr Babula
E-Mail
Guest Editor
Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
Interests: reactive oxygen and nitrogen species; apoptosis; cell deaths
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The cell, subcellular and extracellular component organization at structural, molecular and biophysical levels including the grouping and interrelations of cells in tissues and organs in health and desease still needs investigations. In this special issue, article on various aspects of cell biology e.g. cell compartments, organella and membrane biogenesis and dynamics, macromolecules and their intracellular transport, whole-cell locomotion, cytoskeleton organization, signaling and regulatory cascades, the cell-cycle and cell-to-cell communication are especially welcome. Novel insights into structure, specialization, function and physiology of cells, tissues and organs together with medical aspects of cell biology are invited. Environmental and toxicologic effects on tissue and organ function will be of special interest. Integrative actions of gene and their products, regulatory mechnisms as well as their impact on the development, regeneration of tissue structural and functional status including the use of newly described and advanced methods/techniques will be especially accepted.

Therefore, in this Special Issue of IJMS, we invite you to submit both review and original papers on the topic of widely understood cell biology.

Prof. Dr. Bartosz Jan Płachno
Prof. Dr. Małgorzata Kotula-Balak
Prof. Dr. Petr Babula
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Plant and animal cell
  • Ultrastructure
  • Cell biology
  • Cell development
  • Cell regeneration
  • Cell signaling
  • Tissue histology
  • Tissue physiology and pathology
  • Environemtal effects
  • Toxicology

Published Papers (4 papers)

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Research

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Open AccessArticle
High Temperature Alters Secondary Metabolites and Photosynthetic Efficiency in Heracleum sosnowskyi
Int. J. Mol. Sci. 2021, 22(9), 4756; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094756 - 30 Apr 2021
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Abstract
Due to global warming, invasive species have spread across the world. We therefore studied the impact of short-term (1 day or 2 days) and longer (7 days) heat stress on photosynthesis and secondary metabolites in Heracleum sosnowskyi, one of the important invasive [...] Read more.
Due to global warming, invasive species have spread across the world. We therefore studied the impact of short-term (1 day or 2 days) and longer (7 days) heat stress on photosynthesis and secondary metabolites in Heracleum sosnowskyi, one of the important invasive species in the European Union. H. sosnowskyi leaves exposed to short-term heat stress (35 °C/1 d) showed a decrease in chlorophyll and maximum potential quantum efficiency of photosystem II (Fv/Fm) compared to control, 35 °C/2 d, or 30 °C/7 d treatments. In turn, the high level of lipid peroxidation and increased H2O2 accumulation indicated that the 30 °C/7 d stress induced oxidative damage. The contents of xanthotoxin and bergapten were elevated in the 2 d and 7 d treatments, while isopimpinellin was detected only in the heat-stressed plants. Additionally, the levels of free proline and anthocyanins significantly increased in response to high temperature, with a substantially higher increase in the 7 d (30 °C) treatment. The results indicate that the accumulation of proline, anthocyanins, and furanocoumarins, but not of phenolic acids or flavonols, contributes to protection of H. sosnowskyi plants against heat stress. Further studies could focus on the suppression of these metabolites to suppress the spread of this invasive species. Full article
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Open AccessArticle
Identification of Transcriptomic Differences between Lower Extremities Arterial Disease, Abdominal Aortic Aneurysm and Chronic Venous Disease in Peripheral Blood Mononuclear Cells Specimens
Int. J. Mol. Sci. 2021, 22(6), 3200; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063200 - 21 Mar 2021
Viewed by 472
Abstract
Several human tissues are investigated in studies of molecular biomarkers associated with diseases development. Special attention is focused on the blood and its components due to combining abundant information about systemic responses to pathological processes as well as high accessibility. In the current [...] Read more.
Several human tissues are investigated in studies of molecular biomarkers associated with diseases development. Special attention is focused on the blood and its components due to combining abundant information about systemic responses to pathological processes as well as high accessibility. In the current study, transcriptome profiles of peripheral blood mononuclear cells (PBMCs) were used to compare differentially expressed genes between patients with lower extremities arterial disease (LEAD), abdominal aortic aneurysm (AAA) and chronic venous disease (CVD). Gene expression patterns were generated using the Ion S5XL next-generation sequencing platform and were analyzed using DESeq2 and UVE-PLS methods implemented in R programming software. In direct pairwise analysis, 21, 58 and 10 differentially expressed genes were selected from the comparison of LEAD vs. AAA, LEAD vs. CVD and AAA vs. CVD patient groups, respectively. Relationships between expression of dysregulated genes and age, body mass index, creatinine levels, hypertension and medication were identified using Spearman rank correlation test and two-sided Mann–Whitney U test. The functional analysis, performed using DAVID website tool, provides potential implications of selected genes in pathological processes underlying diseases studied. Presented research provides new insight into differences of pathogenesis in LEAD, AAA and CVD, and selected genes could be considered as potential candidates for biomarkers useful in diagnosis and differentiation of studied diseases. Full article
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Open AccessCommunication
Comprehensive Analysis of Correlations in the Expression of miRNA Genes and Immune Checkpoint Genes in Bladder Cancer Cells
Int. J. Mol. Sci. 2021, 22(5), 2553; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22052553 - 04 Mar 2021
Viewed by 441
Abstract
Personalised medicine is the future and hope for many patients, including those with cancers. Early detection, as well as rapid, well-selected treatment, are key factors leading to a good prognosis. MicroRNA mediated gene regulation is a promising area of development for new diagnostic [...] Read more.
Personalised medicine is the future and hope for many patients, including those with cancers. Early detection, as well as rapid, well-selected treatment, are key factors leading to a good prognosis. MicroRNA mediated gene regulation is a promising area of development for new diagnostic and therapeutic methods, crucial for better prospects for patients. Bladder cancer is a frequent neoplasm, with high lethality and lacking modern, advanced therapeutic modalities, such as immunotherapy. MicroRNAs are involved in bladder cancer pathogenesis, proliferation, control and response to treatment, which we summarise in this perspective in response to lack of recent review publications in this field. We further performed a correlation-based analysis of microRNA and gene expression data in bladder cancer (BLCA) TCGA dataset. We identified 27 microRNAs hits with opposite expression profiles to genes involved in immune response in bladder cancer, and 24 microRNAs hits with similar expression profiles. We discuss previous studies linking the functions of these microRNAs to bladder cancer and assess if they are good candidates for personalised medicine therapeutics and diagnostics. The discussed functions include regulation of gene expression, interplay with transcription factors, response to treatment, apoptosis, cell proliferation and angiogenesis, initiation and development of cancer, genome instability and tumour-associated inflammatory reaction. Full article
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Review

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Open AccessReview
Secondary Metabolites of Plants as Modulators of Endothelium Functions
Int. J. Mol. Sci. 2021, 22(5), 2533; https://doi.org/10.3390/ijms22052533 - 03 Mar 2021
Viewed by 375
Abstract
According to the World Health Organization, cardiovascular diseases are the main cause of death worldwide. They may be caused by various factors or combinations of factors. Frequently, endothelial dysfunction is involved in either development of the disorder or results from it. On the [...] Read more.
According to the World Health Organization, cardiovascular diseases are the main cause of death worldwide. They may be caused by various factors or combinations of factors. Frequently, endothelial dysfunction is involved in either development of the disorder or results from it. On the other hand, the endothelium may be disordered for other reasons, e.g., due to infection, such as COVID-19. The understanding of the role and significance of the endothelium in the body has changed significantly over time—from a simple physical barrier to a complex system encompassing local and systemic regulation of numerous processes in the body. Endothelium disorders may arise from impairment of one or more signaling pathways affecting dilator or constrictor activity, including nitric oxide–cyclic guanosine monophosphate activation, prostacyclin–cyclic adenosine monophosphate activation, phosphodiesterase inhibition, and potassium channel activation or intracellular calcium level inhibition. In this review, plants are summarized as sources of biologically active substances affecting the endothelium. This paper compares individual substances and mechanisms that are known to affect the endothelium, and which subsequently may cause the development of cardiovascular disorders. Full article
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