Special Issue "Cellular Secretomes"
Deadline for manuscript submissions: closed (31 March 2020).
Interests: protein biochemistry; proteomics; mass spectrometry; secretomics
Over the last few decades, the investigation of extracellular molecules has been gaining attention to unravel mechanisms at the basis of cellular communication. The elucidation of cellular secretomes, i.e., the subpopulations of proteins secreted by cells, tissues or organisms, is eliciting a growing interest, mainly related to potential implications in biomarker discovery of diagnostic and prognostic significance. Secreted proteins (e.g., growth factors, cytokines, chemokines, and proteases) are actively involved in the regulation and modulation of intracellular signaling pathways. Furthermore, extracellular signaling molecules also affect tissue niches and surrounding microenvironment, thereby influencing cellular cross-talk and coordinating most cell functions through paracrine or autocrine mechanisms.
The understanding of this molecular language may provide an integrated and broader view of cellular regulatory networks under physiological and pathological conditions, especially in the area of cancer biology.
Given the increasing interest regarding the roles of extracellular molecules in cellular signaling, this Special Issue aims to establish a comprehensive collection of broad knowledge regarding cellular secretome characterization of model systems including cells, stem cells, tumor cells, and biological fluids. Articles addressing potential strategies to profile secreted proteins by proteomics and mass spectrometry-based strategies are all welcome.
Prof. Angela Chambery
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- mass spectrometry