Special Issue "Identification and Characterization of Genetic and Epigenomic Host Factors to Decipher Pathogenic Mechanisms Involved in Cerebral Malaria"
Deadline for manuscript submissions: 31 March 2022.
Interests: severe malaria; infectious diseases; genetic susceptibility/resistance; transcriptomics; genomics; regulatory variants; coding variants; markers of severity
Cerebral malaria due to infection with Plasmodium falciparum is a major cause of childhood morbidity and mortality in endemic regions. No effective vaccine currently exists, and emerging resistance to several antimalarial drugs has become a problem in some regions. A better knowledge of the pathogenic mechanisms would lead to improving diagnosis and treatment and therefore allow better clinical management. Studies in the different areas described below can be very useful in identifying the host factors that have a key role in the development of cerebral malaria.
- Identification of genetic factors through genome-wide association study (GWAS), case-control studies, linkage analysis, exome sequencing, targeting sequencing;
- Functional characterization of regulatory variants associated with cerebral malaria using, for example, bioinformatic prioritization of SNPs, gene reporter assays, and CRISPR-Cas9 technology;
- Transcriptomic approaches and enrichment analysis to identify genes, lncRNAs or miRNAs deregulated in cerebral malaria and pathogenic pathways;
- Investigate epigenomic and transcriptional cooperation to elucidate networks in cerebral malaria which is necessary for the design of targeted therapies;
- Selection of biomarkers that can be used as predictive and prognostic markers for prevention and medical care;
- Use of an animal model to decipher pathogenic processes.
Dr. Sandrine Marquet
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cerebral malaria
- susceptibility gene
- regulatory variant
- coding variant
- pathogenic pathways
- epigenomic factor